Dose and duration of Cd administered

Tissue/Animal

Response to Cd exposure

Reference

0.1, 0.5, 1.0 and 2.0 mg/L for 30 days

Male Swiss albino mice

Dose-dependent increase of ROS in blood stream

Reduced CAT, SOD and GSH-Px enzyme activity in liver, kidney, spleen, testis and brain

[10]

15 mg/kg b.w./day single dose

15 mg/kg b.w./day for 60 days

Male Wistar albino rats

Significant increase in CAT and MDA levels in erythrocytes compared to control group

Significant increase in CAT, GSH-Px, SOD and MDA in erythrocytes compared to control group

[11]

30 mg/kg b.w. for 21 days

Male Wistar rats

Significant increase in MDA levels in blood stream

Significant reduction in GSH, SOD and CAT levels in blood stream

[37]

15 and 100 ppm for 60 days

Male Wistar rats

Increased CAT and SOD levels in heart tissue at 15 ppm dose

Significant increase in CAT levels in heart tissue at 100 ppm

[38]

40 mg/L for 6 weeks

Male albino rats

Significant decreases of CAT, SOD and reduced GSH in plasma significantly reducing the total antioxidant capacity

Significant increase in MDA levels in plasma

[39]

5 mg/kg b.w. for 30 days

Adult male albino Wistar mice

Liver CAT, SOD, GRx and GST were significantly reduced while liver MDA was significantly increased

[40]

50 mg/L for 12 weeks

Male Wistar rats

Decreased activity of SOD and GPx while reducing

levels of GSH and total antioxidant capacity in liver tissues

[41]

10 and 50 ppm for 30 days

Female Sprague-Dawley rats

Elevated blood plasma MT levels till 7 days after exposure

and reduced blood plasma MT levels in the following 2 weeks.

[42]