GO

CP

^*Intragroup comparison at baseline

Baseline

After

P-value

Baseline

After

P-value

P-value

IL-1α

799.1 [1191.2]

683.4 [629.7]

0.25

332.7 [795.7]

370.7 [607.1]

0.48

0.38

IL-1β

73.9 [120.0]

53.8 [68.2]

0.02

46.3 [78.8]

23.6 [33.6]

0.79

0.18

IL-6

2.0 [2.1]

1.2 [1.7]

0.21

1.8 [3.2]

1.8 [0.6]

0.42

0.67

IL-8

218.8 [155.0]

222.0 [112.7]

0.66

161.1 [171.8]

106.5 [94.1]

0.33

0.97

ICAM-1

2007.3 [2856.1]

2157.3 [557.7]

0.42

2255.0 [3246.7]

2038.8 [2310.5]

0.92

0.72

MMP-1

71.0 [92.5]

108.1 [76.8]

0.48

69.3 [52.0]

63.6 [90.2]

0.66

0.92

MMP-3

214.4 [395.9]

206.4 [326.5]

0.48

202.5 [178.1]

91.4 [108.7]

0.13

0.20

MMP-12

142.1 [338.6]

322.5 [370.9]

0.13

231.2 [377.0]

109.1 [162.3]

0.51

0.40

MMP-13

611.6 [3143.6]

1444.0 [2742.7]

0.79

1073.4 [1780.8]

811.9 [1582.1]

0.29

0.72

TGF-β

4.4 [5.6]

3.1 [3.1]

0.01

4.1 [5.1]

1.7 [1.3]

0.29

0.49

TNF-α

1.3 [0.6]

1.8 [1.2]

0.79

1.8 [2.4]

1.4 [1.2]

0.88

0.53

VEGF-A

6.6 [9.9]

7.1 [8.1]

0.25

6.3 [6.7]

6.7 [4.9]

0.33

0.41