Ethanol

TNBS

Oxazolone

6 hpi

72 hpi

6 hpi

72 hpi

6 hpi

72 hpi

IL-1β

1.2 ± 0.2

−1.2 ± 0.2

7.2 ± 15.5*

10.9 ± 12.7**

2.9 ± 3.2*

9.1 ± 8.4**

IL-4/13a

1.5 ± 0.3

−2.2 ± 0.2*

−1.9 ± 0.6

−2.6 ± 0.3*

−1.5 ± 0.4

−3.1 ± 0.1**

IL-4/13b

2.3 ± 0.8

1.1 ± 0.3

−1.2 ± 0.2

2.0 ± 0.3*

−1.0 ± 0.5

4.0 ± 1.5**

IL-6

NA

NA

NA

NA

NA

NA

IL-8

−1.4 ± 0.2

1.2 ± 0.7

1.2 ± 0.9

4.4 ± 3.8*

1.3 ± 1.2

13.8 ± 27.7**

IL-10

1.4 ± 0.4

2.1 ± 0.7*

1.5 ± 0.6

3.3 ± 0.7**

2.3 ± 0.9

1.7 ± 0.9

IL-12

1.8 ± 0.4

1.7 ± 1.1

1.4 ± 2.0

1.2 ± 0.5

1.2 ± 0.6

1.1 ± 0.8

IL-17A1

1.3 ± 0.3

−1.3 ± 0.1

−1.4 ± 0.2

1.7 ± 0.3

2.4 ± 0.7**

−3.6 ± 0.1**

IL-17A2

1.7 ± 2.0

4.0 ± 13.6*

−1.1 ± 14.3

−1.5 ± 0.3

−6.2 ± 0.3

3.6 ± 9.7

IL-17A3

1.1 ± 0.3

1.1 ± 0.6

−6.6 ± 0.2*

1.3 ± 0.4

1.1 ± 0.7

−1.4 ± 0.7

IL-22

2.0 ± 0.2

1.0 ± 0.5

1.7 ± 1.2

2.7 ± 0.8**

−1.4 ± 0.8

1.3 ± 1.3

IL-23

NA

NA

NA

NA

NA

NA

IFN-g

2.4 ± 0.8*

1.1 ± 0.2

1.5 ± 0.8

1.8 ± 0.4

−1.4 ± 0.1

1.8 ± 0.7

TNF-α

1.7 ± 0.6

−1.2 ± 0.4

2.1 ± 0.7*

2.3 ± 1.0*

2.6 ± 1.1*

4.8 ± 8.8*

TGF-β

−1.2 ± 0.1

−1.2 ± 0.1

1.2 ± 0.4

2.3 ± 0.3**

1.2 ± 0.1

2.4 ± 0.4**

mmp9

−1.4 ± 0.5

−1.4 ± 0.2

3.3 ± 1.5*

19.8 ± 40.0**

3.2 ± 0.4**

29.2 ± 46.2**

IgM

1.3 ± 0.4

−2.8 ± 0.5*

−1.4 ± 0.3

−1.6 ± 0.5

1.2 ± 0.4

1.2 ± 0.3

IgZ

2.0 ± 0.4

1.2 ± 0.5

2.5 ± 1.0

2.4 ± 0.7

4.1 ± 0.4

−1.9 ± 0.7

CD4

1.9 ± 0.4

1.0 ± 0.2

−1.3 ± 0.2

−1.6 ± 0.3

1.4 ± 0.2

−1.3 ± 0.2

CD8

−3.7 ± 0.6

−3.3 ± 1.5

−3.0 ± 0.4

−3.0 ± 0.9

−1.0 ± 1.7

−1.4 ± 0.7

C3

−1.3 ± 0.2

−1.2 ± 0.2

−2.4 ± 0.2*

6.4 ± 2.2**

−2.4 ± 0.2

3.4 ± 1.3*

CRP

−1.3 ± 3.2

−1.3 ± 0.4

2.9 ± 10.0

37.6 ± 22.0**

−2.6 ± 0.6

25.8 ± 9.8**

SAA

1.2 ± 0.4

1.4 ± 0.5

4.3 ± 61.3

142.0 ± 182.8**

1.7 ± 2.1

175.9 ± 415.5**

TLR-2

1.9 ± 0.6

−1.4 ± 0.2

−1.9 ± 0.3

1.2 ± 0.5

−1.0 ± 0.5

−2.9 ± 0.1**

TLR-3

1.5 ± 0.5

−1.2 ± 0.1

−1.6 ± 0.2

1.4 ± 0.2

−1.9 ± 0.1

−1.6 ± 0.2

TICAM-1

−1.3 ± 0.4

1.6 ± 1.2

3.0 ± 0.6*

1.3 ± 1.2

2.2 ± 0.8

1.6 ± 1.0

MyD88

1.1 ± 0.3

−1.1 ± 0.1

−1.2 ± 0.2

1.3 ± 0.3

1.7 ± 0.3

1.8 ± 0.5

Foxp3

2.4 ± 0.7

1.4 ± 0.5

3.4 ± 2.4*

−1.2 ± 0.3

4.0 ± 12.4*

1.6 ± 0.5

GATA-3

1.1 ± 0.3

−1.5 ± 0.2

−1.4 ± 0.2

−1.1 ± 0.1

1.5 ± 0.4

−1.5 ± 0.2

NF-κb

1.0 ± 0.2

−1.1 ± 0.1

−1.3 ± 0.2

1.3 ± 0.2

−1.8 ± 0.2

1.2 ± 0.3

STAT-3

1.1 ± 0.2

−1.4 ± 0.1

−1.1 ± 0.2

1.4 ± 0.6

1.1 ± 0.5

1.7 ± 0.3

STAT-4

1.4 ± 0.1

1.1 ± 0.1

−1.3 ± 0.3

1.1 ± 0.3

−1.3 ± 0.1

1.1 ± 0.2

STAT-6

1.3 ± 0.2

−1.6 ± 0.1

−1.0 ± 0.1

1.3 ± 0.3

1.1 ± 0.1

−1.0 ± 0.2

T-bet

3.6 ± 0.6*

−2.1 ± 0.1*

−1.0 ± 0.3

−1.0 ± 0.1

2.1 ± 0.6

−2.1 ± 0.3

S100A1

2.1 ± 0.3*

−1.2 ± 0.2

3.5 ± 1.4**

3.7 ± 0.8**

1.9 ± 0.3

4.2 ± 0.6**