The causative snare protein | Vesicular trafficking that are necessary for cancer cell formation and invasion | Ref. | |
1. Vamp-2 | Alpha 5 beta 1 integrin trafficking, COS-7 cells. | [64] | |
2. Vamp-3 | Integrin intracellular and cell surface distribution, PANC-1 pancreatic cancer cell, and alpha 5 beta 1 integrin trafficking in CHO cells. | [65] [66] | |
3. Vamp-7 | ATP transportation in cancer cell during autophagy stimulation immunogenicity of cancer cell death or inflammation. | [67] | |
4. Vamp-8 | Required for secretion of all platelet granules, Platelets contain α-granules, dense (δ-) granules, and a few lysosomes. | [68] | |
5. Syntaxin-8 | Glioblastoma multiform (GBM): it is driven by aberrant signaling of growth factor receptors (EGFR). Unique tumor suppression mechanism involve the regulation of receptor trafficking. | [69] | |
6. Syntaxin-3 & -4 | Alpha 5 beta 1 and alpha 3 beta 1 integrin trafficking, cervical adenocarcinoma, PANC-1 pancreatic adenocarcinoma. | [70] - [72] | |
7. Syntaxin-3, Vamp-7 & Vamp-8 | Trafficking of serotonin mast cell line for triggering inflammation then cancer cell formation. | [73] [74] | |
8. Syntaxin-6 & Vamp-4 | Cisplatin trafficking in ATP-11B mediated for ovarian cancer cell growth. | [75] | |
9. Syntaxin-6 & Vamp-3 Complex | Alpha 3 beta 1 integrin recycling in HeLa cell and DU145 cells. | [76] [77] | |
10. Syntaxin-6 complex with Vti1b | TNF-α trafficking for Upregulation of complex formation in activated macrophages. | [77] | |
11. Snap-25 | VIP trafficking in neuroblastoma SH-SY5Y cells. | [79] [80] | |
12. Snap-23 & Syntaxin-4 complex | TNF-α in lipopolysaccharides (LPS)-induced macrophages. | [81] | |
13. Snap-23 & Vamp-3 complex | IL-1β induced IL-6 and TNF-α trafficking in human synovial sarcoma cell line. | [82] | |
14. Snap-23, Syntaxin-4 & Vamp-7 | MMP-1 trafficking for proteolysis of ECM in MDA-MB 231-breast cancer cell and HT-1080 fibrosarcoma cell. | [83] [84] | |
15. Snap-23, Syntaxin-13 & Vamp-3 | Beta 1 Integrin mediated Src and EGFR trafficking for invadopodia formation in breast cancer cell. MMP2 and MMP9 is also trafficked in human invasive fibrosarcoma HT-1080 cell line | [85] |