The causative snare protein

Vesicular trafficking that are necessary for cancer cell formation and invasion


1. Vamp-2

Alpha 5 beta 1 integrin trafficking, COS-7 cells.


2. Vamp-3

Integrin intracellular and cell surface distribution, PANC-1 pancreatic cancer cell, and alpha 5 beta 1 integrin trafficking in CHO cells.

[65] [66]

3. Vamp-7

ATP transportation in cancer cell during autophagy stimulation immunogenicity of cancer cell death or inflammation.


4. Vamp-8

Required for secretion of all platelet granules, Platelets contain α-granules, dense (δ-) granules, and a few lysosomes.


5. Syntaxin-8

Glioblastoma multiform (GBM): it is driven by aberrant signaling of growth factor receptors (EGFR). Unique tumor suppression mechanism involve the regulation of receptor trafficking.


6. Syntaxin-3 & -4

Alpha 5 beta 1 and alpha 3 beta 1 integrin trafficking, cervical adenocarcinoma, PANC-1 pancreatic adenocarcinoma.

[70] - [72]

7. Syntaxin-3, Vamp-7 & Vamp-8

Trafficking of serotonin mast cell line for triggering inflammation then cancer cell formation.

[73] [74]

8. Syntaxin-6 & Vamp-4

Cisplatin trafficking in ATP-11B mediated for ovarian cancer cell growth.


9. Syntaxin-6 & Vamp-3 Complex

Alpha 3 beta 1 integrin recycling in HeLa cell and DU145 cells.

[76] [77]

10. Syntaxin-6 complex with Vti1b

TNF-α trafficking for Upregulation of complex formation in activated macrophages.


11. Snap-25

VIP trafficking in neuroblastoma SH-SY5Y cells.

[79] [80]

12. Snap-23 & Syntaxin-4 complex

TNF-α in lipopolysaccharides (LPS)-induced macrophages.


13. Snap-23 & Vamp-3 complex

IL-1β induced IL-6 and TNF-α trafficking in human synovial sarcoma cell line.


14. Snap-23, Syntaxin-4 & Vamp-7

MMP-1 trafficking for proteolysis of ECM in MDA-MB 231-breast cancer cell and HT-1080 fibrosarcoma cell.

[83] [84]

15. Snap-23, Syntaxin-13 & Vamp-3

Beta 1 Integrin mediated Src and EGFR trafficking for invadopodia formation in breast cancer cell. MMP2 and MMP9 is also trafficked in human invasive fibrosarcoma HT-1080 cell line