| Ages Eligible for Study | 18 Years to 45 Years (Adult, Older Adult) |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | No |
| Inclusion Criteria | Exclusion Criteria |
| Written, informed consent | Current or history of a major psychiatric illness, other than drug dependence or disorders secondary to drug abuse |
| 18 years of age or older | Meets DSM-IV criteria for dependence on any drugs other than cocaine, |
| Meets DSM-IV criteria for current cocaine dependence | Physiologically dependent on alcohol and requires medical detoxification |
| Currently seeking treatment for cocaine dependence | Use of prescription drugs within 14 days prior to study entry |
| Currently Not uses cocaine, as determined by a self-report and a negative urine test for cocaine, within 30 days prior to study entry | Use of non-prescription drugs within 7 days prior to study entry |
| Good general health | If female used an oral contraceptive, Depo-Provera, Norplant, or intrauterine progesterone contraceptive system, within 30 days prior to study entry |
| Normal electrocardiogram | Pregnant or breastfeeding |
| Noncustodial, stable residence and phone, plus 1 contact with verifiable address and phone | History of liver disease and evidence of hepatic failure |
| Significant other (eg, spouse, relative) willing to supervise compliance with the study visit schedule and procedures | Current elevated aspartate aminotransferase or alanine aminotransferase levels |
| Completing or recently completed up to 30 days of inpatient treatment for cocaine detoxification for at least 7 days | Participated in any other clinical investigation within 4 weeks prior to study entry |
| Able to provide written informed consent | History of any illness or behavior that, in the opinion of the investigator, might interfere with the study |
| Able to speak English sufficiently to understand the study procedures and provide written informed consent to participate in the study | Family history of early significant cardiovascular disease |
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| Clinically significant medical condition or observed abnormalities (eg: physical exam, electrocardiogram (ECG), lab and/or urinalysis findings) |
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| Current major depression with suicidal ideation, psychosis, bipolar disorder, or any psychiatric disorder that would compromise the ability to complete the study |
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| Known intolerance and/or hypersensitivity to vanoxerine or polylactide-co-glycolide (PLG) |