Subpopulations

Value

Change vector

Risk factors

Presumptive reason

CD3+

abs

Favorable tumor localization

Clonal proliferation of T cells after antigen recognition on APC

CD3+ HLADR+

%

ALL patients

Effective presentation of tumor antigens to T-lymphocytes

CD8+ HLADR+

%

ALL patients

Effective presentation of tumor antigens to cytotoxic T-lymphocytes

CD5+

abs

Favorable tumor localization

Favorable prognostic factor (?)

CD3+ CD2+

abs

Favorable localization

Active T cell penetration in BM

CD3+ CD28+

%

Parameningeal localization of RMS

Efficient antigen presentation with clonal proliferation and accumulation of CD3+CD28+

CD3+ CD28+

%

Alveolar RMS

Anergy of T-lymphocytes, tumor evasion from immune surveillance

CD3+ CD56+

%

Not changed

All groups

Low immunogenicity of RMS

abs

CD3+ CD4+

%

Unfavorable localization

Inhibition of the proliferation of T-helpers or “tumor counterattack”

Alveolar variant

Leu8+ CD4+

%

All RMS patients

Immunodeficiency in patients with RMS

αβTCR

abs

Favorable localization of the primary tumor

Favorable prognostic factor (?)

γδTCR

abs

Favorable localization of the primary tumor

Favorable prognostic factor (?)

γδTCR

%

All RMS patients

Containing the spread of RMS

CD19+ CD5+

abs

Favorable localization

Influence of RMS on the humoral link of immunity