Subpopulations | Value | Change vector | Risk factors | Presumptive reason |
CD3+ | abs | ↑ | Favorable tumor localization | Clonal proliferation of T cells after antigen recognition on APC |
CD3+ HLADR+ | % | ↑ | ALL patients | Effective presentation of tumor antigens to T-lymphocytes |
CD8+ HLADR+ | % | ↑ | ALL patients | Effective presentation of tumor antigens to cytotoxic T-lymphocytes |
CD5+ | abs | ↑ | Favorable tumor localization | Favorable prognostic factor (?) |
CD3+ CD2+ | abs | ↑ | Favorable localization | Active T cell penetration in BM |
CD3+ CD28+ | % | ↑ | Parameningeal localization of RMS | Efficient antigen presentation with clonal proliferation and accumulation of CD3+CD28+ |
CD3+ CD28+ | % | ↓ | Alveolar RMS | Anergy of T-lymphocytes, tumor evasion from immune surveillance |
CD3+ CD56+ | % | Not changed | All groups | Low immunogenicity of RMS |
abs | ||||
CD3+ CD4+ | % | ↓ | Unfavorable localization | Inhibition of the proliferation of T-helpers or “tumor counterattack” |
Alveolar variant | ||||
Leu8+ CD4+ | % | ↓ | All RMS patients | Immunodeficiency in patients with RMS |
αβTCR | abs | ↑ | Favorable localization of the primary tumor | Favorable prognostic factor (?) |
γδTCR | abs | ↑ | Favorable localization of the primary tumor | Favorable prognostic factor (?) |
γδTCR | % | ↑ | All RMS patients | Containing the spread of RMS |
CD19+ CD5+ | abs | ↑ | Favorable localization | Influence of RMS on the humoral link of immunity |