PK parameters | 50 mg/day (n = 20) | 100 mg/day (n = 20) | 150 mg/day (n = 14) |
CL (mL/h/kg) | 19.3 ± 5.9 | 19.8 ± 5.4 | 20.4 ± 5.5 |
AUC0-24 (kg h/mL) | 35.7 ± 8.9 | 74.5 ± 18.7 | 104.3 ± 26.3 |
Cmax (μg/mL) | 4.1 ± 1.4 | 8.0 ± 2.4 | 11.6 ± 3.1 |