PK parameters

50 mg/day (n = 20)

100 mg/day (n = 20)

150 mg/day (n = 14)

CL (mL/h/kg)

19.3 ± 5.9

19.8 ± 5.4

20.4 ± 5.5

AUC0-24 (kg h/mL)

35.7 ± 8.9

74.5 ± 18.7

104.3 ± 26.3

Cmax (μg/mL)

4.1 ± 1.4

8.0 ± 2.4

11.6 ± 3.1