| Echocardiographic Parameters | Baseline (n = 12) | Post-treatment (n = 11*) | P-value |
|
| Right ventricular function |
|
|
|
|
| Normal | 6 (50%) | 11 (100%) | 0.04 |
|
| Mildly depressed | 4 (33%) | 0 (0%) | <0.01 |
|
| Moderately depressed | 2 (17%) | 0 (0%) | <0.01 |
|
| Interventricular septal position |
|
|
|
|
| Normal | 0 (0%) | 4 (36%) | 0.09 |
|
| Flattened septum | 7 (59%) | 7 (64%) | 1.00 |
|
| Bowing into the left ventricle | 5 (42%) | 0 (0%) | 0.04 |
|
| RVSP from TR (mmHg) | 79 ± 23 [40 - 120] | 52 ± 25 [23 - 100] | <0.001 |
|
| Left ventricular ejection fraction (%) | 77 ± 10 [58 - 88] | 71 ± 9.6 [59 - 88] | 0.50 |
|
| Catheterization Parameters | Baseline (n = 7) | Post-treatment (n = 4) | P-value | 95% CI |
| PVRI (Wood units × m2) | 5.06 | 3.14 | 0.140 | −0.77 - 4.62 |
| SVRI (Wood units × m2) | 10.7 | 11.4 | 0.811 | −7.80 - 6.27 |
| PVR/SVR ratio | 0.54 | 0.34 | 0.253 | −0.17 - 0.57 |
| MPAP (mmHg) | 34.4 | 31.0 | 0.443 | −5.67 - 12.9 |
| DPAP (mmHg) | 21.0 | 16.0 | 0.018 | 1.06 - 8.94 |
| Transpulmonary gradient (mmHg) | 23.7 | 18.7 | 0.183 | −2.79 - 12.8 |
| Diastolic pulmonary gradient (mmHg) | 9.5 | 7.0 | 0.403 | −3.87 - 8.87 |
| Laboratory Parameters | Baseline (n = 12) | Post-treatment (n = 12) | P-value | 95% CI |
| NT-proBNP | 21071 | 2037 | <0.001 | 4655 - 33413 |
| Hemoglobin | 11.09 | 11.95 | 0.161 | −2.07 - 0.36 |
| Platelet count | 269.75 | 259.24 | 0.732 | −51.3 - 72.3 |
| Aspartate transaminase | 52.1 | 45.54 | 0.359 | −7.78 - 20.9 |
| Alanine aminotransferase | 43.3 | 32.96 | 0.137 | −3.46 - 24.1 |