Period 1

Period 2

Period 3

Period 4

Period 5

All Periods

A. Availability of tests for presumptive patients

Test performed

n = 595 (%)

n = 1023 (%)

n = 1446 (%)

n = 2148 (%)

n = 1300 (%)

N = 6512 (%)

Culture solid L-J

594 (99.8)

1021 (99.8)

1141 (78.9)

1226 (57.1)

694 (53.4)

4676 (71.8)

Drug sensitivity test

434 (72.9)

588 (57.5)

397 (27.5)

432 (20.1)

180 (13.8)

2031 (31.2)

GeneXpert MTB/RIF

-

-

36 (2.5)

668 (31.1)

608 (46.8)

1312 (26.8)

Culture LJ and/or Xpert MTB/RIF

594 (99.8)

1021 (99.8)

1166 (80.6)

1701 (79.2)

925 (71.2)

5407 (83.0)

B. Patterns of resistance to first line anti-TB drugs

Profile of resistance

n = 434 (%)

n = 588 (%)

n = 397 (%)

n = 432 (%)

n = 180 (%)

N = 2031 (%)

[IC95%]

Sensible to all drugs

129 (29.7)

223 (37.9)

256 (64.5)

147 (34.0)

71 (39.4)

826 (40.7)

[38.6 - 42.8]

Resistance to H

278 (64.1)

306 (52)

124 (31.2)

215 (49.8)

95 (52.8)

1018 (50.1)

[47.9 - 52.3]

Resistance to R

243 (56.0)

289 (49.1)

90 (22.7)

208 (48.1)

96 (53.3)

926 (45.6)

[43.4 - 47.8]

Resistance to E

241 (55.5)

306 (52)

120 (30.2)

242 (56.0)

105 (58.3)

1014 (49.9)

[47.8 - 52.1]

Resistance to S

216 (49.8)

219 (37.2)

97 (24.4)

123 (28.5)

72 (40.0)

727 (35.8)

[33.7 - 37.9]

Total mono resistance

26 (5.9)

46 (7.8)

16 (4.0)

64 (14.8)

3 (1.7)

155 (7.6)

[5.8 - 10.2]

Mono resistance to H

12 (2.8)

7 (1.2)

6 (1.5)

5 (1.2)

0 (0)

30 (1.5)

[1.0 - 2.1]

Mono resistance to R

3 (0.7)

4 (0.7)

0 (0)

6 (1.4)

1 (0.6)

14 (0.7)

[0.4 - 1.2]

Mono resistance to E

5 (1.2)

26 (4.4)

8 (2.0)

52 (12)

2 (1.1)

93 (4.6)

[3.8 - 5.6]

Mono resistance to S

6 (1.4)

9 (1.5)

2 (0.5)

1 (0.2)

0 (0)

18 (0.9)

[0.6 - 1.4]

Total multidrug resistance

229 (52.8)

271 (48.6)

85 (21.4)

193 (44.7)

91 (50.6)

869 (42.8)

[38.4 - 47.8]

H-R

12 (2.8)

13 (2.2)

6 (1.5)

15 (3.5)

2 (1.1)

48 (2.4)

[1.8 - 3.1]

H-R-E

42 (9.7)

77 (13.1)

9 (2.3)

65 (15)

26 (14.4)

219 (10.8)

[9.5 - 12.2]

H-R-S

22 (5.1)

21 (3.6)

6 (1.5)

15 (3.5)

0 (0)

64 (3.2)

[2.5 - 4.0]

H-R-E-S

153 (35.3)

160 (27.2)

64 (16.1)

98 (22.7)

63 (35)

538 (26.5)

[24.6 - 28.5]

Total poly resistance

50 (11.5)

48 (8.2)

40 (10.1)

28 (6.5)

15 (8.3)

181 (8.9)

[6.4 - 12.8]

H-E

10 (2.3)

12 (2.0)

14 (3.5)

13 (3.0)

2 (1.1)

51 (2.5)

[1.9 - 3.3]

H-S

10 (2.3)

5 (0.9)

3 (0.8)

1 (0.2)

1 (0.6)

20 (1.0)

[0.6 - 1.5]

H-E-S

17 (3.9)

11 (1.9)

16 (4.0)

3 (0.7)

1 (0.6)

48 (2.4)

[1.8 - 3.1]

E-S

2 (0.5)

6 (1)

2 (0.5)

2 (0.5)

3 (1.7)

15 (0.7)

[0.5 - 1.2]

R-E

5 (1.2)

7 (1.2)

1 (0.3)

6 (1.4)

4 (2.2)

23 (1.1)

[0.8 - 1.7]

R-S

0 (0)

1 (0.2)

0 (0)

0 (0)

0 (0)

1 (0.1)

[0.0 - 0.3]

R-E-S

6 (1.4)

6 (1)

4 (1.0)

3 (0.7)

4 (2.2)

23 (1.1)

[0.8 - 1.7]

C. The proportion of RR-/MDR-TB versus non RR-/MDR-TB

n = 434 (%)

n = 588 (%)

n = 426 (%)

n = 964 (%)

n = 739 (%)

N = 3151 (%)

[IC 95%]

RR-/MDR-TB

243 (56.0)

289 (49.2)

97 (22.8)

434 (45.0)

501 (67.8)

1564 (49.6)

[47.9 - 51.4]

Non RR-/MDR-TB

191 (44.0)

299 (50.8)

329 (77.2)

530 (55.0)

238 (32.2)

1587 (50.4)

[48.6 -52.1]