Gene mutation codon

MDR-TB

n (%)

Pre-XDR

or

XDR-TB

n (%)

Total

p-value

katG

No mutation

katG 315

katG 320

katG 300

katG 302

katG 314

katG 308

katG 299

katG 340

katG 343

katG 310

katG 312

10 (41.7)

10 (41.7)

1 (4.2)

0 (0.0)

0 (0.0)

1 (4.2)

1 (4.2)

0 (0.0)

3 (12.5)

5 (20.8)

1 (4.2)

1 (4.2)

4 (40.0)

2 (20.0)

0 (0.0)

1 (10.0)

0 (0.0)

0 (0.0)

2 (20.0)

1 (10.0)

1 (10.0)

2 (20.0)

2 (20.0)

3 (30.0)

14 (41.2)

12 (35.3)

1 (2.9)

1 (2.9)

1 (2.9)

1 (2.9)

3 (8.8)

1 (2.9)

4 (11.8)

7 (20.6)

3 (8.8)

4 (11.8)

0.618

0.211

0.706

0.294

0.294

0.706

0.201

0.294

0.666

0.670

0.201

0.067

InhA

No mutation

inhA 14

inhA 25

inhA 78

inhA 81

inhA 84

inhA 86

inhA 94

inhA 114

5 (20.8)

8 (33.3)

1 (4.2)

5 (20.8)

5 (20.8)

6 (25.0)

6 (25.0)

3 (12.5)

5 (20.8)

2 (20.0)

3 (30.0)

0 (0.0)

3 (30.0)

2 (20.0)

3 (30.0)

2 (20.0)

0 (0.0)

6 (60.0)

7 (20.6)

11 (32.4)

1 (2.9)

8 (23.5)

7 (20.6)

9 (26.5)

8 (25.5)

3 (8.8)

11 (32.4)

0.670

0.591

0.706

0.435

0.670

0.538

0.565

0.338

0.036

ahpC

No mutation

ahpC 10

ahpC 12

ahpC 20

ahpC 22

ahpC 75

ahpC 76

14 (58.3)

2 (8.3)

2 (8.3)

3 (12.5)

2 (8.3)

6 (25.0)

5 (20.8)

7 (70.0)

2 (20.0)

2 (20.0)

1 (10.0)

1 (10.0)

1 (10.0)

1 (10.0)

21 (61.8)

4 (11.8)

4 (11.8)

4 (11.8)

3 (8.8)

7 (20.6)

6 (17.7)

0.406

0.334

0.334

0.666

0.662

0.315

0.416