| Baseline | 4 W | 8 W | |||
TSE | Placebo | TSE | Placebo | TSE | Placebo | |
AGEs score in middle finger (a.u.) | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.5 ± 0.1 (0.0 ± 0.1) | 0.5 ± 0.1 (0.0 ± 0.1) | 0.5 ± 0.1 (0.0 ± 0.1) | 0.5 ± 0.1 (0.0 ± 0.1) |
Serum pentosidine (µg/mL) | 0.055 ± 0.006 | 0.054 ± 0.010 | 0.054 ± 0.009 (−0.001 ± 0.008) | 0.053 ± 0.011 (−0.001 ± 0.011) | 0.048 ± 0.007* (−0.007 ± 0.007*) | 0.053 ± 0.009 (0.000 ± 0.009) |
Serum CML (µg/mL) | 4.18 ± 4.60 | 2.98 ± 0.63 | 4.04 ± 4.50 (−0.13 ± 0.28) | 2.84 ± 0.60 (−0.14 ± 0.31) | 4.05 ± 4.91 (−0.16 ± 0.35) | 2.82 ± 0.53 (−0.16 ± 0.35) |