Baseline

4 W

8 W

TSE

Placebo

TSE

Placebo

TSE

Placebo

AGEs score in middle finger (a.u.)

0.5 ± 0.1

0.5 ± 0.1

0.5 ± 0.1

(0.0 ± 0.1)

0.5 ± 0.1

(0.0 ± 0.1)

0.5 ± 0.1

(0.0 ± 0.1)

0.5 ± 0.1

(0.0 ± 0.1)

Serum pentosidine (µg/mL)

0.055 ± 0.006

0.054 ± 0.010

0.054 ± 0.009

(−0.001 ± 0.008)

0.053 ± 0.011

(−0.001 ± 0.011)

0.048 ± 0.007*

(−0.007 ± 0.007*)

0.053 ± 0.009

(0.000 ± 0.009)

Serum CML (µg/mL)

4.18 ± 4.60

2.98 ± 0.63

4.04 ± 4.50

(−0.13 ± 0.28)

2.84 ± 0.60

(−0.14 ± 0.31)

4.05 ± 4.91

(−0.16 ± 0.35)

2.82 ± 0.53

(−0.16 ± 0.35)