Baseline

4 W

8 W

TSE

Placebo

TSE

Placebo

TSE

Placebo

Cheek

Skin moisture

49.6 ± 10.0

54.3 ± 15.2

44.1 ± 15.6

(−5.6 ± 15.4)

45.5 ± 11.4

(−8.8 ± 14.6)

46.9 ± 14.7

(−2.8 ± 16.9)

44.8 ± 12.7

(−9.5 ± 15.5)

TEWL (g/m²·hr)

17.9 ± 6.5

14.0 ± 4.7

18.0 ± 4.9

(0.1 ± 4.7)

16.4 ± 3.6

(2.4 ± 4.0)

15.8 ± 5.9

(−2.2 ± 3.0)

15.1 ± 5.3

(1.1 ± 4.8)

Upper arm

Skin moisture

34.7 ± 9.6

35.1 ± 10.4

31.4 ± 12.6

(−3.3 ± 11.7)

26.0 ± 7.0

(−9.2 ± 12.6)

32.3 ± 8.2

(−2.9 ± 10.7)

29.4 ± 9.8

(−5.8 ± 12.2)

TEWL (g/m²·hr)

9.6 ± 4.8

8.7 ± 2.1

9.6 ± 2.9

(0.0 ± 4.8)

10.3 ± 3.4

(1.6 ± 3.1)

9.6 ± 4.0

(−0.1 ± 6.9)

10.1 ± 3.5

(1.3 ± 3.4)

LEB (µm)

0.0 ± 0.0

9.0 ± 42.2

0.0 ± 0.0

(0.0 ± 0.0)

0.0 ± 0.0

(−9.0 ± 42.2)

0.0 ± 0.0

(0.0 ± 0.0)

0.0 ± 0.0

(−9.0 ± 42.2)

Skin thickness (µm)

1291.0 ± 237.6

1259.8 ± 216.6

1302.9 ± 245.7

(12.0 ± 243.2)

1373.6 ± 276.5

(113.8 ± 251.5)

1326.5 ± 282.9

(64.5 ± 266.5)

1363.9 ± 253.3

(104.1 ± 184.1)

Intensity

26.3 ± 12.3

26.4 ± 10.0

22.4 ± 9.3

(−3.9 ± 10.0)

21.7 ± 7.6

(−4.7 ± 9.8)

27.9 ± 14.5

(0.8 ± 13.0)

23.6 ± 8.5

(−2.7 ± 8.2)