δ-hemolysin and its variants

Classification

Sequence

Original

Amino acid

MAQDIISTIGDLVKWIIDTVNKFTKK

G = H at pH 2

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 2

HHPPHHPHHPPHHPHHHPHHPPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHPPHHPHHHPHHPPHHPP

Variant position 3, Q→A

Amino acid

MAADIISTIGDLVKWIIDTVNKFTKK

G = H at pH 2

HHHPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 2

HHHPHHPHHPPHHPHHHPHHPPHHPP

G = H at pH 7

HHHPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHHPHHPHHPPHHPHHHPHHPPHHPP

Variant positions 10 - 12, GDL→VEF

Amino acid

MAQDIISTIVEFVKWIIDTVNKFTKK

G = H at pH 2

HHPPHHPHHHHHHPHHHPHHPPHHPP

G = P at pH 2

HHPPHHPHHHHHHPHHHPHHPPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

Variant position 15, W→L

Amino acid

MAQDIISTIGDLVKLIIDTVNKFTKK

G = H at pH 2

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 2

HHPPHHPHHPPHHPHHHPHHPPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHPPHHPHHHPHHPPHHPP

Variant positions 17 - 18, ID→AE

Amino acid

MAQDIISTIGDLVKWIAETVNKFTKK

G = H at pH 2

HHPPHHPHHHPHHPHHHHHHPPHHPP

G = P at pH 2

HHPPHHPHHPPHHPHHHHHHPPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHPPHHPHHHPHHPPHHPP

Variant position 21, N→E

Amino acid

MAQDIISTIGDLVKWIIDTVEKFTKK

G = H at pH 2

HHPPHHPHHHPHHPHHHPHHHPHHPP

G = P at pH 2

HHPPHHPHHPPHHPHHHPHHHPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHPPHHPHHHPHHPPHHPP

Variant position 24, T→I

Amino acid

MAQDIISTIGDLVKWIIDTVNKFIKK

G = H at pH 2

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 2

HHPPHHPHHPPHHPHHHPHHPPHHPP

G = H at pH 7

HHPPHHPHHHPHHPHHHPHHPPHHPP

G = P at pH 7

HHPPHHPHHPPHHPHHHPHHPPHHPP