Laboratory

code

Chemical name

Basis of design

Protein kinases activation

Trk neurotrophin receptor

Akt

Erk

GK-2

bis-(N-monosuccinyl-L-glutamyl-L-lysine)hexamethylenediamide

Central fragment of NGF loop 4 beta-turn:

-Glu⁹⁴-Lys⁹⁵-

TrkA

+

−

GSB-106

bis-(N-monosuccinyl-L-seryl- L-lysine) hexamethylenediamide

Central fragment of BDNF loop 4 beta-turn:

-Ser⁹⁴-Lys⁹⁵-

TrkB

+

+

GSB-214

bis-(N-monosuccinyl-L-methionyl- L-serine) heptamethylenediamide

Central fragment of BDNF loop 1 beta-turn:

-Met³¹-Ser³²-

TrkB

+

−