| Upregulated DEGs | Degree | Survival related hub genes | Upregulated DEGs | Degree | Survival related hub genes |
| CDK1 | 97 | CDK1 | UBE2T | 67 | UBE2T |
| CCNB1 | 94 | CCNB1 | KIFC1 TK1 | 66 | KIFC1 TK1 |
| CCNB2 | 91 | CCNB2 | SPC25 EZH2 | 65 | SPC25 EZH2 |
| CDC20 CCNA2 AURKA | 90 | CDC20 CCNA2 AURKA | CDCA3 HELLS | 63 | CDCA3 HELLS |
| MAD2L1 TOP2A | 89 | MAD2L1 TOP2A | GMNN ATAD2 | 62 |
|
| BUB1B | 87 | BUB1B | MND1 | 61 |
|
| BUB1 AURKB KIF2C | 85 | BUB1 AURKB KIF2C | SKA1 KIF18B CCNE2 | 60 | SKA1 KIF18B CCNE2 |
| NDC80 KIF20A TTK RRM2 | 84 | NDC80 KIF20A TTK RRM2 | FAM83D E2F8 | 59 | FAM83D E2F8 |
| CDC6 TPX2 DLGAP5 UBE2C NCAPG BIRC5 NUSAP1 PBK MKI67 | 83 | CDC6 TPX2 DLGAP5 NCAPG BIRC5 NUSAP1 PBK MKI67 | CKAP2 CKAP2L | 57 | CKAP2 CKAP2L |
| CDC7 | 53 | CDC7 | |||
| STIL | 50 | STIL | |||
| ASPM MELK | 82 | ASPM MELK | GINS1 | 46 | GINS1 |
| CDKN3 | 81 |
| SGOL2 | 44 | SGOL2 |
| ZWINT NUF2 CENPF RACGAP1 HMMR PRC1 RAD51AP1 | 80 | ZWINT NUF2 CENPF RACGAP1 HMMR PRC1 RAD51AP1 | TCF19 | 36 | TCF19 |
| MSH2 H2AFZ | 35 | MSH2 H2AFZ | |||
| CENPE PTTG1 EXO1 KIF4A CDCA5 | 79 | CENPE PTTG1 EXO1 KIF4A CDCA5 | STMN1 CD34 | 25 | STMN1 CD34 |
| TUBA1C | 24 | TUBA1C | |||
| CENPA KIAA0101 | 78 | CENPA KIAA0101 | SPP1 | 23 | SPP1 |
| FOXM1 DTL | 77 | FOXM1 DTL | ACLY | 21 |
|
| TRIP13 | 76 | TRIP13 | NQO1 | 20 | NQO1 |
| NEK2 | 75 | NEK2 | PSMD4 | 19 |
|
| MCM2 MCM4 RFC4 | 74 | MCM2 RFC4 | EME1 | 16 | EME1 |
| ECT2 | 73 | ECT2 | TXNRD1 | 15 |
|
| HJURP MCM3 CDC25C | 72 | HJURP MCM3 CDC25C | LCN2 | 14 |
|
| MCM6 CKS2 ANLN | 70 | MCM6 CKS2 ANLN | CCT3 ITGA6 | 12 | CCT3 |
| KPNA2 UHRF1 | 69 | KPNA2 UHRF1 | AKR1C3 TKT THY1 NME1 ILF2 | 11 | AKR1C3 ILF2 |
| SKA3 CKS1B | 68 | SKA3 CKS1B | GPC3 TFRC CDKN2C | 10 | CDKN2C |
| Downregulated DEGs | Degree | Survival related hub genes | Downregulated DEGs | Degree | Survival related hub genes |
| ESR1 | 38 | ESR1 | CXCL12 ACAA1 PCK1 | 15 | PCK1 |
| IGF1 FTCD | 26 | IGF1 FTCD | C8B ALDH2 LPA CFP NR1I2 C9 HAO2 ACSL1 | 14 | C8B ALDH2 LPA CFP NR1I2 HAO2 ACSL1 |
| CYP3A4 | 25 | CYP3A4 | |||
| FOS | 24 |
| ACADS LCAT CYP2A6 CYP2C8 CYR61 CYP4A11 FOXO1 | 13 | ACADS LCAT CYP2C8 CYP4A11 FOXO1 |
| CYP2B6 SPP2 | 21 | SPP2 | |||
| C8A CYP2E1 TAT F9 | 20 | C8A CYP2E1 TAT F9 | IGFBP3 ACAA2 DCN LIPC SLC10A1 C1R HGFAC | 12 | LIPC DCN SLC10A1 HGFAC |
| MBL2 CYP2C9 C6 | 18 | CYP2C9 C6 | |||
| CYP1A2 ASS1 | 17 |
| KMO ADH4 HMGCL CYP4F2 PLA2G16 | 11 | ADH4 HMGCL CYP4F2 |
| EGR1 CTH CYP26A1 KLKB1 ALDH8A1 | 16 | CTH KLKB1 ALDH8A1 | IDO2 ACACB ALPL EPHX2 ACSM3 GCDH HAMP GNMT PROZ ETFDH | 10 | ALPL EPHX2 ACSM3 GCDH GNMT PROZ ETFDH |