IHC Index	Immune response					The overall positive Rate (%)	≥++ positive Rate (%)
IHC Index	−	+	++	+++	Total	The overall positive Rate (%)	≥++ positive Rate (%)
P53	92	44	71	61	268	65.7%	49.3%
P16	161	38	35	31	265	39.2%	24.9%
CyclinD1	82	71	68	44	265	69.1%	42.3%
Ki67	44	85	101	38	268	83.5%	51.9%