*Laboratory criteria | |
・ Uric acid ≥ 8 mg/dl (476 µmol/mL) ・ Phosphorus ≥ 4.5mg/dl (1.45 mmol/L) ・ Potassium ≥ 6 mEq/L (6.0 mmol/L) ・ Corrected calcium ≤ 7 mg/dL (1.75 mmol/L) | or a 25% increase from baseline or a 25% increase from baseline or a 25% increase from baseline or a 25% decrease from baseline |
*Clinical criteria | |
・ Creatinine ≥ 1.5 times the upper limit of normal ・ Cardiac arrhythmia or sudden death ・ Seizure *May not be directly related to a therapeutic agent |