*Laboratory criteria

・ Uric acid ≥ 8 mg/dl (476 µmol/mL)

・ Phosphorus ≥ 4.5mg/dl (1.45 mmol/L)

・ Potassium ≥ 6 mEq/L (6.0 mmol/L)

・ Corrected calcium ≤ 7 mg/dL (1.75 mmol/L)

or a 25% increase from baseline

or a 25% increase from baseline

or a 25% increase from baseline

or a 25% decrease from baseline

*Clinical criteria

・ Creatinine ≥ 1.5 times the upper limit of normal

・ Cardiac arrhythmia or sudden death

・ Seizure *May not be directly related to a therapeutic agent