Factors

Group

PFS

OS

HR

95% CI

p value

HR

95% CI

p value

Age

continuous

1.003

0.937 - 1.075

0.923

0.882

0.777 - 1.002

0.053

ECOG-PS

1.2 vs. 0

1.839

0.668 - 5.057

0.238

1.570

0.303 - 8.136

0.591

Baseline PSA (ng/dL)

continuous

1.001

0.998 - 1.003

0.499

1.002

0.998 - 1.006

0.276

≥100 vs. <100

1.103

0.432 - 2.813

0.838

2.556

0.628 - 10.407

0.190

Baseline ALP (IU/l)

≥359 vs. <359

1.269

0.497 - 3.237

0.618

1.147

0.306 - 4.305

0.839

Baseline LDH (IU/l)

≥229 vs. <229

1.689

0.647 - 4.412

0.285

1.161

0.286 - 4.714

0.835

Baseline hemoblobin (g/dl)

<11.1 vs. 11.1<

1.566

0.608 - 4.028

0.353

2.227

0.526 - 9.436

0.277

Biopsy Gleason Score

≤8 vs. >8

1.214

0.389 - 3.790

0.738

1.261

0.313 - 5.082

0.744

Visceral metastasis

Yes vs. No

2.276

0.773 - 6.704

0.136

6.139

1.229 - 30.671

0.027*

PSA ≥ 50% decline in previous DP

No vs. Yes

1.637

0.563 - 4.763

0.365

3.743

0.455 - 30.800

0.220

Total cycles of previous DP

≤6 vs. >6

1.283

0.476 - 3.455

0.622

1.062

0.253 - 4.460

0.935

Duration from CRPC to DEC (month)

≤12 vs. >12

3.055

1.015 - 9.202

0.047*

5.790

1.148 - 29.215

0.033*