group

dose

percentage of cumulative FITC leakage/%

15 min

30 min

45 min

60 min

75 min

90 min

105 min

120 min

medium control

-

1.74 ± 0.38

2.10 ± 0.45

2.59 ± 0.59

3.22 ± 0.69

3.51 ± 0.65

3.94 ± 0.79

4.14 ± 0.79

4.42 ± 0.81

DMSO control

-

1.74 ± 0.61

2.07 ± 0.77

2.49 ± 0.90

3.07 ± 1.04

3.36 ± 1.08

3.79 ± 1.15

3.91 ± 1.09

4.19 ± 1.14

TTE

10 μg・ml⁻¹

1.45 ± 0.28

1.73 ± 0.41

2.04 ± 0.50

2.41 ± 0.51

2.66 ± 0.51

3.02 ± 0.59

3.15 ± 0.55

3.37 ± 0.54

40 μg・ml⁻¹

1.77 ± 0.01

2.18 ± 0.12

2.55 ± 0.11

3.12 ± 0.17

3.36 ± 0.14

3.69 ± 0.08

3.83 ± 0.10

4.09 ± 0.11

160 μg・ml⁻¹

8.08 ± 3.30

10.40 ± 4.16

11.74 ± 3.89*

13.34 ± 4.05*

14.05 ± 3.91*

15.51 ± 4.44*

15.56 ± 4.44*

16.08 ± 4.45*

640 μg・ml⁻¹

40.23 ± 4.95**

51.85 ± 3.17***

59.36 ± 2.39***

63.73 ± 2.61***

65.55 ± 2.04***

70.74 ± 4.64***

68.31 ± 4.49***

68.67 ± 4.41***

medium control

-

1.44 ± 0.09

1.97 ± 0.14

2.23 ± 0.13

2.47 ± 0.08

2.87 ± 0.07

3.32 ± 0.07

3.64 ± 0.06

3.88 ± 0.04

DMSO control

-

1.77 ± 0.24

2.67 ± 0.31

3.03 ± 0.34

3.11 ± 0.31

3.34 ± 0.27

3.55 ± 0.25

3.77 ± 0.24

3.92 ± 0.22

triptolide

4 ng・ml⁻¹

3.34 ± 0.14**

4.50 ± 0.13**

4.88 ± 0.15**

4.92 ± 0.26**

5.14 ± 0.30**

5.32 ± 0.34**

5.53 ± 0.38**

5.62 ± 0.39**

16 ng・ml⁻¹

3.07 ± 0.34**

4.34 ± 0.41**

4.62 ± 0.41**

4.67 ± 0.40**

4.90 ± 0.40**

5.07 ± 0.37**

5.26 ± 0.36**

5.38 ± 0.34**

64 ng・ml⁻¹

2.41 ± 0.12*

3.43 ± 0.15*

3.72 ± 0.17*

3.76 ± 0.15*

3.99 ± 0.17*

4.18 ± 0.18*

4.40 ± 0.19*

4.52 ± 0.19*

256 ng・ml⁻¹

5.75 ± 0.64**

8.07 ± 0.70**

9.32 ± 0.80**

9.53 ± 0.89**

10.19 ± 1.03**

10.75 ± 1.03**

11.37 ± 1.02**

11.88 ± 1.07**