Variables | Control a | T2DM b | T2DM/AS c | p value a & b | p value a & c | p value b & c |
Allele n (%) | n = 162 | n = 186 | n = 62 |
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ε2 | 70 (86.4) | 82 (91.1) | 28 (90.3) | 0.23 | 0.42 | 0.42 |
ε3 | 76 (84.0) | 87 (84.4) | 29 (83.9) | 0.55 | 0.60 | 0.60 |
ε4 | 16 (19.8) | 17 (18.9) | 5 (16.1) | 0.52 | 0.44 | 0.44 |
Genotype n (%) | n = 81 | n = 90 | n = 31 |
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ε2/ε3 | 57 (70.4) | 68 (75.6) | 23 (74.2) | 0.28 | 0.44 | 0.44 |
ε2/ε4 | 13 (16.0) | 14 (15.6) | 5 (16.1) | 0.55 | 0.60 | 0.60 |
ε2/ε2 | / | / | / | / | / | / |
ε3/ε3 | 8 (9.9) | 5 (5.6) | 3 (9.7) | 0.22 | 0.64 | 0.64 |
ε3/ε4 | 3 (3.7) | 3 (3.3) | / | 0.61 | 0.37 | 0.37 |
ε4/ε4 | / | / | / | / | / | / |
HWE |
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rs7412 (ε2) | 39.63 (p < 0.0001) | 55 (p < 0.0001) | 16.35 (p = 0.00005) | / | / | / |
rs429358 (ε4) | 0.27 (p = 0.60) | 0.43 (p = 0.51) | / | / | / | / |