Reference

Type of the study

Results

Conclusions

Panagiotakopoulos et al. [9]

A study with 105 hospitalized pregnant women with SARS-CoV-2 infection.

13.3% of pregnant women were admitted to the ICU. Among them, six required mechanical ventilation, and one died. The number of pregnant women with GD was 15.2%. Also, 36.2% had pre-pregnancy obesity.

Despite the higher percentages of GD and pre-pregnancy obesity in pregnant women hospitalized for COVID-19 without obstetric reason, more information is needed to understand the effects caused by SARS-CoV-2 during pregnancy and its complications.

Pirjani et al. [10]

Prospective cohort study 199 pregnant women (15 - 46 years old), 66 pregnant women infected with SARS-CoV-2 and 133 uninfected pregnant women who formed the control group.

There was no significant relationship between COVID-19 infection and complications from comorbidities, including GD. Despite this, infected patients had a higher percentage of admission to the ICU compared to the control group.

No significant differences were observed between clinical manifestations and pregnancy complications in infected and uninfected women.

Kayem et al. [11]

Series of cases involving 617 pregnant women in 33 maternity centers in France were diagnosed with COVID-19, of which 497 (80.6%) were symptomatic.

Of the women who were associated with a severe form of the disease, who had comorbidities such as DMG, it was seen that one died, and 85.3% of these women gave birth, 79.3% of whom were premature.

The study found that those women who had comorbidities such as DMG had COVID-19 more severely. Critically ill women had a high rate of premature birth.

Sun et al. [12]

Case-control study with 60 of pregnant women confirmed to have COVID-19 and 120 controls.

Compared to the control group, 21.67% of the pregnant women in the case group were diagnosed with GD. They presented high levels of neutrophils and low levels of total protein. White blood cell levels of pregnant women with COVID-19 without diabetes were higher than the levels of the diabetes control group.

The study shows that chronic diseases may potentialize the inflammatory response to COVID-19. The focus on diabetes is hyperglycemia, which can increase the inflammatory response plus to compromise the regeneration’s ability of the liver, causing it liver injury.