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| Dose Groups | Parameters | Experimental days |
| Acute | Induction | Washout | Expression | ||||||
| 1 | 2 | 7 | 8 | 10 | 11 |
| ED 2 vs.1 | ED 7 vs. 2 | ED 8 vs. 1 | ED 10 vs. 1 | ED 11 vs. 2 | |||
| ADOLESCENT | 0.6 mg/kg MPD | MESOR | 55 | 62 | 66 | 56 | 67 | 59 | p-value | 0.478 | 0.677 | 0.881 | 0.268 | 0.794 |
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| F-stat | 0.504 | 0.174 | 0.023 | 1.232 | 0.068 | ||
| Amplitude | 30.34 | 37.73 | 51.20 | 48.34 | 30.12 | 37.03 | p-value | 0.588 | 0.457 | 0.196 | 0.989 | 0.962 | ||
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| F-stat | 0.294 | 0.556 | 1.682 | 0.000 | 0.002 | ||
| Acrophase | 14.50 | 14.42 | 14.86 | 15.21 | 16.62 | 15.78 | p-value | 0.952 | 0.746 | 0.590 | 0.240 | 0.451 | ||
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| F-stat | 0.004 | 0.105 | 0.292 | 0.001 | 0.569 | ||
| 2.5 mg/kg MPD | MESOR | 65 | 61 | 59 | 58 | 65 | 54 | p-value | 0.691 | 0.811 | 0.453 | 0.946 | 0.398 | |
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| F-stat | 0.158 | 0.057 | 0.565 | 0.005 | 0.716 | ||
| Amplitude | 38.20 | 32.93 | 34.05 | 46.94 | 52.40 | 38.39 | p-value | 0.722 | 0.938 | 0.527 | 0.330 | 0.685 | ||
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| F-stat | 0.127 | 0.006 | 0.400 | 0.952 | 0.165 | ||
| Acrophase | 14.31 | 14.21 | 15.88 | 15.44 | 15.88 | 15.95 | p-value | 0.941 | 0.229 | 0.318 | 0.173 | 0.160 | ||
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| F-stat | 0.006 | 1.452 | 1.000 | 1.865 | 1.989 | ||
| 10.0 mg/kg MPD | MESOR | 65 | 56 | 67 | 56 | 67 | 54 | p-value | 0.433 | 0.452 | 0.360 | 0.791 | 0.794 | |
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| F-stat | 0.617 | 0.639 | 0.842 | 0.070 | 0.068 | ||
| Amplitude | 35.63 | 54.24 | 74.74 | 54.28 | 45.34 | 51.85 | p-value | 0.254 | 0.314 | 0.198 | 0.533 | 0.882 | ||
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| F-stat | 1.308 | 1.016 | 1.664 | 0.391 | 0.022 | ||
| Acrophase | 13.90 | 13.10 | 13.20 | 13.69 | 15.94 | 14.79 | p-value | 0.545 | 0.926 | 0.857 | 0.132 | 0.087 | ||
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| F-stat | 0.367 | 0.009 | 0.033 | 2.281 | 2.945 | ||
| ADULT | 0.6 mg/kg MPD | MESOR | 45 | 58 | 75 | 83 | 86 | 76 | p-value | 0.112 | 0.131 | 0.000 | 0.000 | 0.111 |
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| F-stat | 2.536 | 2.298 | 14.320 | 18.400 | 2.561 | ||
| Amplitude | 25.36 | 52.28 | 74.27 | 61.42 | 72.69 | 80.04 | p-value | 0.026 | 0.225 | 0.019 | 0.001 | 0.124 | ||
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| F-stat | 5.000 | 1.480 | 5.548 | 10.880 | 2.380 | ||
| Acrophase | 11.96 | 13.86 | 14.12 | 14.75 | 15.36 | 14.97 | p-value | 0.161 | 0.787 | 0.095 | 0.036 | 0.237 | ||
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| F-stat | 1.980 | 0.073 | 2.810 | 4.422 | 1.404 | ||
| 2.5 mg/kg MPD | MESOR | 67 | 58 | 73 | 85 | 88 | 90 | p-value | 0.184 | 0.052 | 0.037 | 0.002 | 0.000 | |
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| F-stat | 1.774 | 3.821 | 4.397 | 9.451 | 15.280 | ||
| Amplitude | 34.53 | 45.25 | 86.00 | 86.40 | 93.46 | 83.37 | p-value | 0.295 | 0.001 | 0.000 | 0.000 | 0.004 | ||
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| F-stat | 1.101 | 12.000 | 15.770 | 31.590 | 8.415 | ||
| Acrophase | 12.52 | 12.81 | 13.72 | 14.19 | 14.41 | 14.36 | p-value | 0.750 | 0.175 | 0.095 | 0.018 | 0.042 | ||
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| F-stat | 0.101 | 1.853 | 2.810 | 5.651 | 4.184 | ||
| 10.0 mg/kg MPD | MESOR | 58 | 56 | 74 | 69 | 76 | 56 | p-value | 0.777 | 0.140 | 0.183 | 0.035 | 0.996 | |
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| F-stat | 0.081 | 2.189 | 1.787 | 4.510 | 0.000 | ||
| Amplitude | 45.51 | 67.17 | 72.54 | 76.86 | 80.65 | 55.56 | p-value | 0.104 | 0.782 | 0.020 | 0.010 | 0.448 | ||
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| F-stat | 2.668 | 0.077 | 5.490 | 6.729 | 0.578 | ||
| Acrophase | 12.63 | 12.53 | 13.04 | 13.09 | 13.80 | 13.79 | p-value | 0.903 | 0.565 | 0.581 | 0.161 | 0.122 | ||
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| F-stat | 0.015 | 0.333 | 0.306 | 1.978 | 2.406 | |||||||