Items | Week | SEM | Week | P-value | |||||||||||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | In utero TRT × week | Heifer TRT × week | In utero TRT × Heifer TRT × week | |||
n= | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 |
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Glucose Tolerance test | |||||||||||||||||||||
Peak Glu (mg/100 mL) | 257 | 242 | 229 | 207 | 192 | 177 | 161 | 156 | 19.3 | 0.01 | 0.05 | 0.50 | 0.42 | ||||||||
Peak time (min) | 2.8 | 3.2 | 3.1 | 3.3 | 3.5 | 3.8 | 3.9 | 4.3 | 1.03 | 0.93 | 0.23 | 0.80 | 0.72 | ||||||||
Glucose disappearance (%/min) | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.09 | <0.01 | 0.17 | 0.88 | 0.37 | ||||||||
Glucose t1/2 (min) | 140.7 | 119 | 95.6 | 76.5 | 62.4 | 45.9 | 27.8 | 8.3 | 45.57 | 0.54 | 0.68 | 0.71 | 0.19 | ||||||||
Glucose AUC ((mg/mL) × 180 min) | 27,683 | 23,872 | 21,866 | 17,951 | 15,870 | 12,377 | 9802 | 6922 | 4947 | <0.01 | 0.75 | 0.72 | 0.08 | ||||||||
Baseline metabolites | |||||||||||||||||||||
Glucose (mg/100 mL) | 101.6 | 91.6 | 93.7 | 87 | 93.1 | 77.4 | 81.5 | 68.7 | 75.6 | 62 | 61.6 | 57.5 | 55.8 | 48.8 | 47 | 35.8 | 14.72 | <0.01 | 0.74 | 0.24 | 0.80 |
Urea N (mg/100 ml) | 10.8 | 13.7 | 9.6 | 12.3 | 11.7 | 11 | 9.6 | 10.4 | 10.6 | 11.2 | 8.7 | 9.5 | 7.4 | 5.6 | 4.9 | 5.6 | 2.43 | <0.01 | 0.56 | 0.98 | 0.99 |
NEFA (mmol/L) | 490 | 374 | 283 | 229 | 239 | 183 | 201 | 195 | 239 | 205 | 239 | 270 | 265 | 275 | 310 | 344 | 90.8 | <0.01 | <0.01 | 0.88 | 0.74 |
β-hydroxybutrate (mg/100 mL) | 0.1 | 0.17 | 0.17 | 0.2 | 0.13 | 0.24 | 0.22 | 0.22 | 0.22 | 0.29 | 0.24 | 0.28 | 0.31 | 0.29 | 0.29 | 0.29 | 0.125 | <0.01 | 0.28 | 0.86 | 0.87 |