Virus

Name

Tumor

Modified HSV

gene

ICP34.5/LAT

(bp)

Additional

modification

Replication activity reduction

Ref

HSV-1 (F)

M032

Brain tumors

ICP34.5

2 kb replaced in the γ34.5 and ORF P.

IL12

About 100 times

[35]

HSV-1 (F)

NG34

Glioblastoma

ICP6,

ICP34.5

1000-bp deletions in both γ34.5 genes

GADD34

About 100 times

[31]

HSV-1 (F)

G47Δ

Melanoma

ICP34.5

ICP6

ICP47

1000-bp deletions in both γ34.5 genes

-

About 100 times

[33]

HSV-1 (F)

NV1020

Metastatic colorectal cancer

ICP34.5

ICP4

ICP0

Δ1.5 kb over the joint region

(ICP34.5/4/0)

-

About 100 times

[34]

HSV-1 (F)

G207

Glioblastoma

ICP34.5 deletion ICP6

1000-bp deletions in both γ34.5 genes

LacZ

About 10 - 100 times

[32]

HSV-1 (17)

HSV1716

Solid cancers

ICP34.5 deletion

ΔICP34.5

125,213 - 125,972

-

About 10 - 100 times

[36]

HSV-1 (17)

RH018

Gliosarcoma, melanoma

ICP47

ICP34.5

ΔICP34.5

124,954 - 125,726

GALV-GP-R, MGM-CSF

Not mentioned

[11]

HSV-1 (JS-1)

T-VEC

Medulloblastoma Melanoma

ICP34.5 deletion, US11 deletion

ΔICP34.5

124,948 - 125,713

GM-CSF

About 10 - 100 times

[37]

HSV-1 (CL1)

OrienX010

Glioblastoma

ICP34.5 deletion, ICP47 deletion,

ΔICP34.5

completely deleted

GM-CSF insertion

Not mentioned

[38]

HSV-1 (McKrae)

DM33

Glioblastomas

Brain tumors

Deleted

γ34.5 and LAT

ΔLAT1 76 to 1667 (Contains the entire ICP34.5)

LAT was replaced by GFP

Not mentioned

[17]

HSV-1 (HF)

HF10

Superficial cancers, melanoma

UL56 LAT

116.515  to 120.346 (UL56 and LAT)

UL52, UL53, UL54, UL55

Not mentioned

[39]