Virus | Name | Tumor | Modified HSV gene | ICP34.5/LAT (bp) | Additional modification | Replication activity reduction | Ref |
HSV-1 (F) | M032 | Brain tumors | ICP34.5 | 2 kb replaced in the γ34.5 and ORF P. | IL12 | About 100 times | [35] |
HSV-1 (F) | NG34 | Glioblastoma | ICP6, ICP34.5 | 1000-bp deletions in both γ34.5 genes | GADD34 | About 100 times | [31] |
HSV-1 (F) | G47Δ | Melanoma | ICP34.5 ICP6 ICP47 | 1000-bp deletions in both γ34.5 genes | - | About 100 times | [33] |
HSV-1 (F) | NV1020 | Metastatic colorectal cancer | ICP34.5 ICP4 ICP0 | Δ1.5 kb over the joint region (ICP34.5/4/0) | - | About 100 times | [34] |
HSV-1 (F) | G207 | Glioblastoma | ICP34.5 deletion ICP6 | 1000-bp deletions in both γ34.5 genes | LacZ | About 10 - 100 times | [32] |
HSV-1 (17) | HSV1716 | Solid cancers | ICP34.5 deletion | ΔICP34.5 125,213 - 125,972 | - | About 10 - 100 times | [36] |
HSV-1 (17) | RH018 | Gliosarcoma, melanoma | ICP47 ICP34.5 | ΔICP34.5 124,954 - 125,726 | GALV-GP-R, MGM-CSF | Not mentioned | [11] |
HSV-1 (JS-1) | T-VEC | Medulloblastoma Melanoma | ICP34.5 deletion, US11 deletion | ΔICP34.5 124,948 - 125,713 | GM-CSF | About 10 - 100 times | [37] |
HSV-1 (CL1) | OrienX010 | Glioblastoma | ICP34.5 deletion, ICP47 deletion, | ΔICP34.5 completely deleted | GM-CSF insertion | Not mentioned | [38] |
HSV-1 (McKrae) | DM33 | Glioblastomas Brain tumors | Deleted γ34.5 and LAT | ΔLAT1 76 to 1667 (Contains the entire ICP34.5) | LAT was replaced by GFP | Not mentioned | [17] |
HSV-1 (HF) | HF10 | Superficial cancers, melanoma | UL56 LAT | 116.515 to 120.346 (UL56 and LAT) | UL52, UL53, UL54, UL55 | Not mentioned | [39] |