Method | Advantage | Disadvantage | Mainly References |
Dose | There are conversion formulas such as weight or body surface area; More accurate calculation | The effective amount used in different animals is inconsistent; Excessive dose can cause death of small animals | [13] [15] |
Speed | Fast onset, high bioavailability, easy to control blood concentration | The speed is difficult to control, resulting in inaccurate results; Need infusion pump, syringe pump and other instruments to control the speed | [15] [21] [22] [27] |
Concentration | Simple and convenient to use the dilution method | There is no standard conversion formula to rely on; Inaccurate estimates can lead to animal poisoning reactions | [15] [21] [22] |
Time | Effectiveness, increase the success rate of modeling; Correlation, associated with dose, speed, and concentration | There is a lack of standard standards for medication time, time interval and days of modeling | [18] [25] [27] |