Drugs	Dose	Duration	Side effect	Reference
1) Gabapentinoids				[31]
- Gabapentin	−1800 - 3600 mg/day	Three times a day, variable titration twice daily,	Diarrhea, dry mouth; warning for increased risk of suicidal thoughts dizziness, somnolence, peripheral edema
- Gabapentin enacarbil	1200 mg/day	4-day to 1-week titration
- Gastroretentive gabapentin	−1800 mg once daily	2-week titration
- Pregabalin	−150 - 600 mg/day	Two or three times a day; 1-week titration
2) Opioids				[31]
- Tramadol	100 to 400 mg per day	Multiple daily dosing, variable titration	Dependence, nausea, vomiting, anorexia, seizure threshold decreased, sedation, dizziness, confusion, dependence
- Morphine - Oxycodone - Methadone	Variable dose and titration	Multiple daily dosing, variable titration
3) Tricyclic antidepressant				[32]
- Amitriptyline - Desipramine - Nortriptyline	Up to 150 mg per day	Multiple daily dosing; variable titration	Sedation, dry mouth, blurred vision, constipation, urinary retention	[32]
4) Tropical agent and creams				[33]
- Capsaicin 0.075% cream	Applied 3 or four times per day	Every 3 months or longer	Burning skin, Pruritis
- Capsaicin 8% patch	Up to four patches for 1 hour		Burning skin, Pruritis
- Lidocaine 5% patch (Lidoderm)	Maximum three patches per day		Mild skin rxn
5) Ozone therapy	1000 microgram	3 times per week for 4 - 6 weeks	Not much	[34]