Case (Reference number)

Age (Yrs)

Sex

Indication for SMX-TMP, number of doses

Rhabdomyolysis-related signs, symptoms, and laboratory findings

Days until symptom onset

Creatine

Kinase Level (U/L) max

Days until recovery post positive dechallenge, CK (U/L) at recovery

Confounding etiologic factors

1

(14)

40

F

UTI^[A], 4

Muscle tenderness, Myalgia, Weakness, SCr 1.5 mg/dL (0.6 - 1.1 mg/dL)

2

20 063

NA, 760

None reported

2

(15)

64

M

UTI^[B], 7

Myoglobinuria, Myalgia, Tea-colored urine, elevated transaminases, lactate dehydrogenase, mild acidosis, hyponatremia, hypocalcemia, hyperuricemia

5 [2] †

64 691

6 days, 4720

NSAIDs*, CYP2C9 inhibition

3 (Our patient report)

43

F

UTI^[C], 5

Proteinuria, Myalgia, elevated transaminases, hyponatremia,

hypocalcemia

2

45 020

8 days, 2809

‡Alcoholism, atypical antidepressant