Time (hours)

F1

(% drug release)

F2

(% drug release)

F3

(% drug release)

F4

(% drug release)

0

0.05

0.13

0.11

0.09

1

16.16

22.97

21.34

20.55

2

32.44

38.92

36.4

33.55

3

47.94

52.23

51.22

47.49

4

53.61

60.32

58.15

55.61

5

59.63

65.49

64.6

63.79

6

64.59

75.62

73.55

72.29

7

73.41

81.88

79.35

78.17

8

78.11

88.29

80.36

79.20

9

78.26

89.03

80.44

78.79

10

78.35

89.96

79.63

78.57

11

78.44

90.57

78.95

78.49

12

77.26

90.94

78.93

78.21