Treatment | Urine volume (ml) | |||||||||
1 hr | 2 hr | 3 hr | 4 hr | 5 hr | 24 hr | 2nd day | 3rd day | 4th day | 5th day | |
10% DMSO | 0.56 ± 0.15 | 1.41 ± 0.27 | 2.20 ± 0.37 | 2.85 ±0.41 | 3.45 ± 0.37 | 6.40 ± 0.94 | 9.08 ± 1.33 | 11.68 ± 1.24 | 16.30 ± 1.63 | 22.31 ± 1.55 |
Furosemide 20 mg/kg | 4.25 ± 0.28** | 5.96 ± 0.16** | 6.28 ± 0.24** | 7.61 ± 0.23** | 8.25 ± 0.12** | 15.51 ± 0.48** | 26.18 ± 2.94** | 29.93 ± 3.28** | 32.71 ± 3.16** | 37.56 ± 3.36** |
C. jwarancusa 150 mg/kg | 0.62 ± 0.14 | 1.40 ± 0.20 | 2.33 ± 0.16 | 2.95 ± 0.26 | 3.40 ± 0.26 | 6.41 ± 0.46 | 11.73 ± 0.84 | 16.08 ± 1.33 | 21.08 ± 0.88 | 27.23 ± 0.94 |
C. jwarancusa 300 mg/kg | 0.95 ± 0.15 | 1.88 ± 0.35 | 2.85 ± 0.47 | 3.6 ± 0.51 | 4.23 ± 0.49 | 8.75 ± 0.77 | 14.55 ± 1.57 | 20.75 ± 2.08* | 26.66 ± 1.72* | 30.33 ± 1.94 |
C. jwarancusa 500 mg/kg | 1.36 ± 0.2* | 2.71 ± 0.37* | 3.66 ± 0.20* | 5.13 ± 0.75* | 5.75 ± 0.72* | 9.51 ± 1.31* | 17.91 ± 1.99* | 26.16 ± 2.95* | 30.25 ± 3.09* | 34.0 ± 3.14* |