Animal no.

C_max (µg/mL)

T_max (h)

AUC_0−t (ng/mL/h)

AUC_0−∞ (ng/mL/h)

R

T

R

T

R

T

R

T

1

1.0515

1.4823

2.25

2.75

3194.9

3627.4

3330.4

3660.4

2

0.7851

1.0238

2.25

2.00

1866.0

1518.1

2021.4

1543.7

3

0.7111

0.4310

2.50

2.00

1998.0

784.2

2120.3

889.2

4

0.4320

0.8134

2.00

2.75

450.8

2040.1

474.6

2158.4

5

1.2963

1.1512

2.75

2.50

1651.5

2964.1

1939.5

3457.5

6

0.5251

0.6540

2.25

2.25

1031.9

2537.8

1069.6

3359.4

Mean

0.8002

0.9260

2.33

2.37

1698.8

2245.2

1825.9

2511.4

SD

0.3252

0.3746

0.25

0.34

933.8

1021.5

979.7

1151.2