(a) Morphine | ||
Parameter | Vehicle | Diclofenac |
Tmax (min) | 15.0 ± 0002 | 15.0 ± 0.002 |
Cmax (μg/ml) | 3.90 ± 0.180 | 7.2 ± 0.189* |
AUC (mg/ml∙min) | 0.132 ± 0.0368 | 0.282 ± 0.0247* |
t1/2 (min) | 22.0 ± 0.472 | 21.0 ± 0.389 |
Vd (L/kg) | 2.70 ± 0.970 | 1.40 ± 0.337* |
CLtot (L/hr/kg) | 0.033 ± 0.00953 | 0.018 ± 0.00152* |