| LORIS | LORD | COMET | LORRETA |
Phase | III | III | III | III |
Study | AS | AS | AS + ET | AS + ET |
Screening | MMG | MMG | MMG | MMG, US, MRI |
Nuclear Grade | 1 or 2 | 1 | 1 or 2 | 1 or 2 |
Comedo Necrosis | No | No | Eligible | No |
ER | N/S | N/S | Positive | Positive |
HER2 | N/S | N/S | Negative | Negative |
Size | N/S | Any Size | Any Size | Equal or less 2.5 cm |
Patient/Target | 113/932 | 25/1240 | 182/1200 | 27/340 |