○ Presence of mass, increased density around calcifications, architectural distortion, stellate lesion on mammography ○ Presence of bilateral DCIS ○ Presence of Paget’s disease, invasive breast cancer, or pleomorphic LCIS ○ Presence of symptomatic DCIS e.g. DCIS detected by palpation or nipple discharge ○ Presence of synchronous invasive carcinoma in the contralateral breast ○ Prior history of invasive breast cancer or DCIS ○ Prior history of other cancer except carcinoma in situ of the cervix or basocellular carcinoma of the skin ○ Presence of serious disease that precludes definitive surgical treatment (e.g. cardiovascular/pulmonary/renal disease ○ Individual with a family member with a known gene mutation associated with increased risk of breast cancer, unless study participant is a proven non-carrier of mutation ○ Presence of pregnancy or breast-feeding ○ Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial |