○ Previous or current diagnosis of invasive breast cancer or previous ipsilateral DCIS (previous surgically treated contralateral DCIS is permitted)

○ A mass lesion clinically on imaging at the site of the micro-calcification which has not been proven on biopsy to be a specific benign lesion

○ Surgical procedure with curative intent (even if clear margins have not been achieved)

○ Unequivocal comedo necrosis observed

○ Any serious and/or unstable pre-existing condition that would prevent compliance with the trial or the consent process

○ Recent onset ipsilateral blood-stained nipple discharge without benign explanation

○ High risk group for developing breast cancer (as defined in current NICE guidelines for familial breast cancer, or due to prior exposure to mantle field radiotherapy