| Nystatin | Sequesters cholesterol and prevents viral attachment, entry and or fusion | decreases | Viral Entry by HSV-1 | Causal | 1 |
| Penciclovir | Guanosine nucleoside analogue | decreases increases | HL, Infection by HSV Inhibition of HSV/HSV-1 | Causal | 9 |
| Pentosan Polysulfate | Interferes with viral adsoprtion | decreases | Replication of HSV | Causal | 1 |
| Prednisolone Phosphate | Anti-inflammatory | decreases | HSK | Causal | 1 |
| PRO 2000 | N/A | decreases | HG | Causal | 1 |
| Pyrithione | Prevents activation of NF-κB by interfering with proteasome function | increases | Inhibition of HSV-1 | Causal | 2 |
| Resiquimod | Toll-like recpetor 7 agonist | decreases | Infection by HSV | Causal | 1 |
| Trichosanthin | Type I ribosome-inactivating protein | affects increases | Replication of HSV-1 Inhibition of HSV-1 | Causal | 2 |
| Trifluridine | Thymidine nucleoside analogue | decreases increases | Infection by HSV Inhibition of HSV-1 | Causal | 2 |
| Valacyclovir | Prodrug of acyclovir | decreases increases | HG, HL, Infection by HSV Inhibition of HSV-1 | Causal | 20 |
| Vidarabine | Adenosine nucleoside analogue | decreases | Infection by HSV | Causal | 1 |
| Zinc Gluconate | Interferes with viral glycoproteins and prevents membrane fusion | decreases | HL | Causal | 1 |