| Chemical Drugs | Molecule Function | Effect on Disease or Function | Disease or Function | Causal or Correlated | Findings |
| 2-deoxyglucose | Modified glucose that prevents viral and entry and acts as a glycosylation inhibitor | decreases | HSK | Causal | 1 |
| 3-deazaaristeromycin | Broad acting antiviral that induces significant increase in interferon | decreases | Replication of HSV-1 | Causal | 1 |
| Acyclovir | Guanosine nucleoside analogue | decreases increases | HG, HL, HSE, HSK, Infection by HSV, Replication of HSV/HSV-1 Inhibition of HSV/HSV-1 | Causal | 35 |
| Amenamevir | Helicase-primase inhibitor | decreases | Infection by HSV, Replication of HSV-1 | Causal | 5 |
| Brivudine | Thymidine nucleoside analogue | decreases increases | HL, HG, HSE, HSK, Infection by HSV Inhibition of HSV-1 | Causal | 7 |
| Celgosivir | α-glucosidase I inhibitor | decreases | Quantity of HSV-1 | Causal | 1 |
| Cidofavir | Cytidine nucleoside analogue | increases | Inhibition of HSV-1 | Causal | 2 |
| Dextran Sulfate | Glycosoaminoglycan analogue | decreases | Replication of HSV-1 | Causal | 1 |
| Docosanol | Aliphatic alcohol that inhibits viral envelope-cell membrane fusion | decreases | HL | Causal | 2 |
| Epigallocatechin-gallate | Catechin that likely inhibts viral attachment, entry, and or fusion | increases | Inactivation of HSV-1 | Causal | 2 |
| Famciclovir | Guanosine nucleoside analogue | decreases increases | HG, HL, Infection by HSV-1, Replication of HSV-1 Inhibition of HSV-1 | Causal | 19 |
| Foscarnet | Mimics pyrophosphate anion and binds DNA polymerase to inhibit activity | increases | Inhibition of HSV-1 | Causal | 2 |
| Ganciclovir | Guanosine nucleoside analogue | increases | Inhibition of HSV | Causal | 2 |
| Idoxuridine | Thymidine nucleoside analogue | decreases increases | Infection by HSV Inhibition of HSV-1 | Causal | 1 |
| Imiquimod | Toll-like recpetor 7 agonist | decreases increases | Infection by HSV, Replication of HSV-1 Inhibition of HSV-1 | Causal | 3 |
| Lipopolysaccharide | May decrease susceptibility to viral infection | decreases | Infection by HSV-1 | Causal | 1 |
| ME 609 | Acyclovir-hydrocortisone combination | decreases | HL | Causal | 3 |
| Methyl-β- cyclodextrin | Removes cholesterol from membranes and prevents/reduces viral entry | decreases | Viral Entry by HSV-1 | Causal | 5 |
| Mycophenolic acid | Depletes GTP levels and enhances nucleoside analgoue activity | increases | Inhibition of HSV | Causal | 6 |
| NB001 | Nanoemulsion that disrupts viral envelope | decreases | HL | Causal | 2 |