Method

Pharmacological drugs

Outcome of trials

References

Double-blind crossover study

Sulfamethoxazole-trimethoprim

Improved spasticity or rigidity, rather than ataxia

Ogawa M

Cerebellum. 2004; 3(2):107-11.

Double-blind randomized study

Buspirone, a 5-HT1A agonist

The effect is partial on ataxia, not major

Ogawa M

Cerebellum. 2004; 3(2):107-11.

Double-blind placebo-controlled randomized study

5‐hydroxytryptophan

Improving neurological symptoms

Trujillo-Martín MM, Serrano-Aguilar P, Monton-Alvarez F, Carrillo-Fumero R

MovDisord. 2009 Jun 15; 24(8):1111-24.

Double-blind, placebo-controlled crossover trial

Tetrahydobiopterin

Short-term effect

Sakai T, Antoku Y, Matsuishi T, Iwashita H

J Neurol Sci. 1996 Mar; 136(1-2):71-2.

Double-blind randomized study

Taltireline hydrate, fluoxetin, tandospirone and lamotrigine

Some Positive results were reported

Shirasaki H, Ishida C, Nakajima T, Kamei H, Koide T, Fukuhara N

RinshoShinkeigaku. 2003 Apr; 43(4):143-8.