Group Category Description # Human Gene Symbols

PDE1 CaM-dependent PDE 3 PDE1A-PDE1C

PDE2 cGMP-stimulated PDE 1 PDE2A

PDE3 cGMP-inhibited PDE 2 PDE3A, PDE3B

PDE4 cAMP-specific PDE 4 PDE4A-PDE4D

PDE5 cGMP-specific PDE 1 PDE5A

PDE6 Photoreceptor PDE 6 PDE6A-C, PDE6D, PDE6G, PDE6H

PDE7 cAMP-specific PDE 2 PDE7A, PDE7B

PDE8 cAMP-specific PDE 2 PDE8A, PDE8B

PDE9 cGMP-specific PDE 1 PDE9A

PDE10 dual specificity PDE 1 PDE10A

PDE11 dual specificity PDE 1 PDE11A

ENPP ectonucleotide PPase/PDE 7 ENPP1-7

SMase sphingomyelin PDE, neutral 2 SMPD2, SMPD3

ASM sphingomyelin PDE, acid-like 3 SMPD1, SMPDL3A, SMPDL3B

GDPD glycerophosphodiester PDE 6 GDPD1-5, MIR16

CNP 2'3'-cyclic nucleotide 3' PDE 1 CNP

Controls 5 18S, ACTB, B2M, GAPDH, PPIA

TOTAL 48