| TEST | |||
|
| RT-PCR | Serology | PRNT |
| Samplesa | Serum, Urine, CSF | CSF, Serum | Serum, urine |
| Detection of infection | Recent | Recent | Confirms the presence of zika-specific IgM. Also measures IgG |
| Remarks | Prone to False-negative results in recent infections | Sensitive but not specific to the ZIKV as other flaviviruses antibodies can cross-react. Need confirmation with PRNT | Prone to False-positive in patients with previous flaviviral infection or vaccination. Might not distinguish maternal from fetal IgG within the first 18 months of life. |