Molecular Characterization

Species

Serotype

Genotypes

Authors

C. neoformans var. grubii

A

VNI, VNIII, VNB

C. gattii, C. bacillisporus, C. deuterogattii,

Hurst et al., 2019 [15]

C. tetragattii and C. decagattii

B/C

VGI-IV

Hagen et al., 2015 [14]

Virulence

Authors

Survival at mammalian body temperature

Production of polysacharide capsule

Rone-Egstron et al., 2001 [21] ; Ruane et al., 1988 [22]

Production of melanin

Pini et al., 2017 [24] ; Lev et al., 2013 [25] ;

Positive urease

Casadevall and Pirofski, 2012 [18]

Phospholipase

Diagnosis

Authors

Detection of glucuronoxylomannan (GXM)

Cryptococcus antigen latex test (CALAT)

Khodati et al., 2017 [28] ;

Multiplex PCR

Tone et al., 2016 [27] ;

Analysis of the ITS1 and ITS2 regions