S/N

circRNA

Function

Mechanism

Reference

1

circRNA

Translation potential

From their parental genes

[21] Pamudurti et al., 2017;

[8] Ungerleider et al., 2018

2

Endogenous translatable circRNAs [30] [30]

Translation potential

Associated with polysome

[30] Yang et al., 2017

3

has_circ_0041407

Translation potential

Internal ribosome entry site (IRES)

[30] Yang et al., 2017

4

circ-ZNF609

Translated into functional proteins

Cap-independent and

splicing-dependent manner

[29] Legnini et al., 2017

5

circRNAs

modulating RNA splicing

[21] Pamudurti et al., 2017

6

circRNAs

Regulation gene expression

Transcriptional, post-transcriptional,

and translational

[19] [37] Wang et al., 2017; Zhang et al., 2017

7

CircBHLF1

and circBHLF1alt

Activation of lytic

viral DNA replication

[8] Ungerleider et al., 2018

8

circLMP2

EBV reactivation

Facilitating Cp initiated

transcript diversity

[8] Ungerleider et al., 2018

circRPMS1

Supporting EBV tumour

phenotype in stomach cancer

circEBNA

Associated with type III latency

9

ciRS-7

miRNAinhibitor

[38] [39] Peng et al., 2015; Hansen et al., 2013

circBART

[7] Toptan et al., 2018

10

circ-Foxo3

Blocks cell cycle

Formation of circ-Foxo3/CDK2/p21 complex that prevent interaction between p21 and cyclin A and that between CDK2 with cyclin E and p27 as such block transition of cell cycle from G1 to S phase

[40] , [41] Fischer & Leung, 2017; Du et al., 2017

11

circHIPK3

Blocks cell cycle

[42] Zheng et al., 2016

12

Circ-Foxo3

Interfere with subcellular

localisation of proteins

[40] Fischer & Leung, 2017

13

Purified circRNAs

(Only circRNA generated by self-splicing and not with spliceosome)

Confer protection

against viral infection

Activates RIG-I and by

offsetting the effects of miRNAs

on target gene expression

[26] Chen et al., 2017

[19] Wang et al., 2017