S/N | circRNA | Function | Mechanism | Reference |
1 | circRNA | Translation potential | From their parental genes | [21] Pamudurti et al., 2017; [8] Ungerleider et al., 2018 |
2 | Endogenous translatable circRNAs [30] [30] | Translation potential | Associated with polysome | [30] Yang et al., 2017 |
3 | has_circ_0041407 | Translation potential | Internal ribosome entry site (IRES) | [30] Yang et al., 2017 |
4 | circ-ZNF609 | Translated into functional proteins | Cap-independent and splicing-dependent manner | [29] Legnini et al., 2017 |
5 | circRNAs | modulating RNA splicing |
| [21] Pamudurti et al., 2017 |
6 | circRNAs | Regulation gene expression | Transcriptional, post-transcriptional, and translational | [19] [37] Wang et al., 2017; Zhang et al., 2017 |
7 | CircBHLF1 and circBHLF1alt | Activation of lytic viral DNA replication |
| [8] Ungerleider et al., 2018 |
8 | circLMP2 | EBV reactivation | Facilitating Cp initiated transcript diversity | [8] Ungerleider et al., 2018 |
circRPMS1 | Supporting EBV tumour phenotype in stomach cancer | |||
circEBNA | Associated with type III latency | |||
9 | ciRS-7 | miRNAinhibitor |
| [38] [39] Peng et al., 2015; Hansen et al., 2013 |
circBART | [7] Toptan et al., 2018 | |||
10 | circ-Foxo3 | Blocks cell cycle | Formation of circ-Foxo3/CDK2/p21 complex that prevent interaction between p21 and cyclin A and that between CDK2 with cyclin E and p27 as such block transition of cell cycle from G1 to S phase | [40] , [41] Fischer & Leung, 2017; Du et al., 2017 |
11 | circHIPK3 | Blocks cell cycle |
| [42] Zheng et al., 2016 |
12 | Circ-Foxo3 | Interfere with subcellular localisation of proteins |
| [40] Fischer & Leung, 2017 |
13 | Purified circRNAs (Only circRNA generated by self-splicing and not with spliceosome) | Confer protection against viral infection | Activates RIG-I and by offsetting the effects of miRNAs on target gene expression | [26] Chen et al., 2017 [19] Wang et al., 2017 |