Term

Description

Genes

FDR

Biological processes

GO:0055114

Oxidation-reduction process

ME1, HSD3B3, ACADSB, NDUFB5, NDUFB6, CYP3A25, EHHADH, CYP2B9, PAH, UQCRFS1, ALDH3A2, BBOX1, FMO3, HSD17B6, CAT, CYP2C54, CYP3A16, CYP3A11, CYP2C29, IDO2, FADS2, CYP1A2, CYP2C50, CYP4A10, HAO2, CYP8B1

2.60E−17

GO:0008152

Metabolic process

HSD3B3, ACADSB, EHHADH, ECHDC1, PAH, ACSS3, ALDH3A2, AFMID, GSTM1, AADAC, TYMP, ACSL1, PYGL, PKLR, AACS, ACAA1B, UGP2

1.89E−09

GO:0006629

Lipid metabolic process

HACL1, ACADSB, ACSL1, SULT2A1, EHHADH, APOC3, HSD17B6, FADS2, CYP1A2, AACS, ACAA1B, THRSP

3.76E−04

GO:0006631

Fatty acid metabolic process

CYP4A10, ACADSB, APOA2, ACSL1, EHHADH, FADS2, AACS, ACAA1B

0.0011

GO:0019373

Epoxygenase P450 pathway

CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50

0.003784

GO:0042493

Response to drug

APOA2, ACSL1, ABCB11, ABAT, ABCD3, CAT, UQCRFS1, AACS

0.169252

GO:0006810

Transport

TTR, NDUFB5, APOA2, NDUFB6, ABCB11, SLC2A2, APOC3, ABCA8A, ABCD3, FADS2, UQCRFS1, ATP5J

38.61568

Cellular component

GO:0031090

Organelle membrane

CYP4A10, AADAC, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, FMO3, CYP2C29, CYP1A2, CYP8B1, CYP2C50

1.00E−11

GO:0005739

Mitochondrion

ME1, ETNPPL, HSD3B3, FKBP8, ACADSB, NDUFB5, NDUFB6, EHHADH, UQCRFS1, AGXT, ACSS3, ALDH3A2, BBOX1, GLS2, ACSL1, ABCD3, GCSH, CAT, ACAA1B, ATP5J, LACTB2, GM4952, GCK, HAO2, ABAT, OAT

4.24E−08

GO:0005789

Endoplasmic reticulum membrane

REEP6, HSD3B3, CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, FADS2, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, CYP8B1

6.94E−07

GO:0043231

Intracellular membrane-bounded organelle

CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, ABCD3, HSD17B6, CAT, CYP8B1

1.56E−06

GO:0005783

Endoplasmic reticulum

REEP6, HSD3B3, CYP2C54, CYP3A25, CYP3A16, CYP2B9, CYP3A11, CYP2C29, FADS2, CYP1A2, ALDH3A2, CYP2C50, AADAC, CYP4A10, ACSL1, FMO3, HSD17B6, CAT, CES1E, CYP8B1, CES1C

3.58E−06

GO:0005777

Peroxisome

HACL1, ACSL1, EHHADH, HAO2, ABCD3, CAT, ACAA1B, AGXT

2.27E−04

GO:0005829

Cytosol

ME1, SULT2A5, SULT2A1, EHHADH, ECHDC1, ALDH3A2, INMT, AFMID, TYMP, APOA2, GCK, SLC2A2, APOC3, PKLR, CAT, AACS, THRSP

0.145049

GO:0005743

Mitochondrial inner membrane

HSD3B3, NDUFB5, NDUFB6, ABCA8A, ABCD3, UQCRFS1, ALDH3A2, ATP5J

0.259456

GO:0005759

Mitochondrial matrix

GLS2, ACADSB, ABAT, OAT, AGXT, LACTB2

0.369843

GO:0070062

Extracellular exosome

ACADSB, ABCB11, ECHDC1, PAH, ALDH3A2, BBOX1, CYP4A10, TTR, APOA2, PYGL, APOC3, PKLR, HAO2, ABAT, CAT, UGP2

20.70699

Molecular function

GO:0016491

Oxidoreductase activity

ME1, HSD3B3, ACADSB, CYP2C54, CYP3A25, CYP3A16, CYP2B9, EHHADH, CYP3A11, CYP2C29, IDO2, FADS2, PAH, CYP1A2, UQCRFS1, ALDH3A2, BBOX1, CYP2C50, CYP4A10, HAO2, FMO3, HSD17B6, CAT, CYP8B1

5.09E−15

GO:0004497

Monooxygenase activity

CYP4A10, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, FMO3, CYP2C29, PAH, CYP1A2, CYP8B1, CYP2C50

1.79E−10

GO:0020037

Heme binding

CYP3A25, CYP3A16, CYP2C54, CYP3A11, CYP2B9, CYP2C29, IDO2, CYP1A2, CYP2C50, CYP4A10, CYP2A22, CAT, CYP8B1

1.52E−09

GO:0005506

Iron ion binding

CYP3A25, CYP3A16, CYP2C54, CYP3A11, CYP2B9, CYP2C29, PAH, CYP1A2, BBOX1, CYP2C50, CYP4A10, CYP2A22, CYP8B1

1.47E−08

GO:0070330

Aromatase activity

CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2, CYP2C50

5.45E−08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4A10, CYP2C54, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2, CYP8B1, CYP2C50

9.66E−08

GO:0003824

Catalytic activity

ETNPPL, HACL1, HSD3B3, EHHADH, ECHDC1, PAH, ACSS3, AGXT, ACSL1, PYGL, PKLR, HAO2, ABAT, AACS, OAT, ACAA1B

1.39E−07

GO:0016712

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A22, CYP3A16, CYP3A25, CYP3A11, CYP2B9, CYP2C29, CYP1A2

1.03E−05

GO:0008392

Arachidonic acid epoxygenase activity

CYP4A10, CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50

8.90E−04

GO:0008395

Steroid hydroxylase activity

CYP2A22, CYP2C54, CYP2B9, CYP2C29, CYP2C50

0.053216

GO:0030170

Pyridoxal phosphate binding

ETNPPL, PYGL, ABAT, OAT, AGXT

0.057234

GO:0016740

Transferase activity

SULT2A5, ETNPPL, SULT2A1, AGXT, INMT, GSTM1, GM4952, TYMP, GCK, PYGL, PKLR, ABAT, OAT, ACAA1B, UGP2

0.788706

GO:0042803

Protein homodimerization activity

GSTM1, APOA2, PYGL, ABAT, ABCD3, PAH, CAT, AGXT, THRSP

9.244787

GO:0046872

Metal ion binding

ME1, HACL1, CYP2C54, CYP3A25, CYP3A16, CYP3A11, CYP2B9, CYP2C29, IDO2, PAH, CYPF2, UQCRFS1, LACTB2, BBOX1, CYP2C50, CYP4A10, PKLR, ABAT, CAT, CYP8B1, UGP2

14.20634

GO:0042802

Identical protein binding

ETNPPL, TTR, HACL1, FKBP8, ABAT, OAT, UGP2

27.05591