| Term | Description | Genes | FDR |
| Biological processes | |||
| GO:0002376 | Immune system process | H2-K1, IRGM1, C3, S100A9, PML, ANXA1, SAMHD1, SERPING1, GBP2B, PSMB8, CD74, PSMB9, LCN2, IFIT3, FGG, IFIT1, FGA, SERPINA3G, FGB, TAP2, TAP1, CFH, H2-AA, IIGP1, CD14, ZBP1 | 5.75E−21 |
| GO:0045087 | Innate immune response | IRGM1, C3, S100A9, ANXA1, PML, SAMHD1, SERPING1, IFIT3, LCN2, FGG, IFIT1, FGA, FGB, CFH, IIGP1, CD14, ZBP1 | 4.88E−09 |
| GO:0035458 | Cellular response to interferon-beta | IFIT3, IFIT1, IRGM1, GBP6, IGTP, IIGP1, GBP2B, GBP2 | 3.57E−07 |
| GO:0002250 | Adaptive immune response | FGG, FGA, FGB, SERPINA3G, TAP2, TAP1, ANXA1, CD74 | 0.001988979 |
| GO:0006953 | Acute-phase response | ORM1, SERPINA3N, ITIH4, STAT3, FN1 | 0.016555934 |
| GO:0034097 | Response to cytokine | SERPINA3K, SERPINA3N, SERPINA3G, ITIH4, PML, STAT3 | 0.026453654 |
| GO:0006879 | Cellular iron ion homeostasis | LCN2, HPX, HMOX1, CP, FTH1 | 0.045710521 |
| GO:0051607 | Defense response to virus | IFIT3, IFIT1, PML, SAMHD1, GBP2B, OAS1G, ZBP1 | 0.080418113 |
| GO:0019882 | ~antigen processing and presentation | H2-K1, H2-AA, CD74, PSMB8, PSMB9 | 0.094415132 |
| GO:0010466 | Negative regulation of peptidase activity | SERPINA3K, SERPINA3N, PZP, SERPINA3G, ITIH4, SERPING1 | 0.154739303 |
| GO:0043434 | Response to peptide hormone | SERPINA3K, SERPINA3N, GATM, SERPINA3G, ANXA1 | 0.306643017 |
| GO:0007160 | Cell-matrix adhesion | FGG, FGA, FGB, ITGB2, FN1 | 0.395726443 |
| GO:0007596 | Blood coagulation | FGG, FGA, C3, FGB, SERPING1 | 0.52544175 |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | EGFR, FGG, FGA, C3, FGB, CD74 | 1.369527162 |
| GO:0045766 | Positive regulation of angiogenesis | C3, LRG1, HMOX1, ITGB2, ANXA3 | 2.056385341 |
| GO:0071222 | Cellular response to lipopolysaccharide | LCN2, GBP6, GBP2, CD14, CMPK2 | 13.58949423 |
| GO:0006955 | Immune response | H2-K1, H2-AA, OAS1G, FTH1, CD74 | 29.72515146 |
| Cellular component | |||
| GO:0070062 | Extracellular exosome | ALDOA, FKBP5, C3, LGMN, VIM, G6PDX, S100A9, ITGB2, FTH1, IQGAP1, CD74, RAB7, TPM3, FGG, LGALS3BP, FAM49B, FGA, LRG1, FGB, ITIH4, CFH, TGM2, FGL1, FN1, ARHGDIB, H2-K1, GBP6, GATM, ANXA1, SERPING1, CLIC1, PSMB8, ANXA3, PSMB9, LCN2, ARPC1B, SERPINA3K, SERPINA3N, HPX, CP, GBP4, LCP1, CD14, MVP | 7.76E−16 |
| GO:0072562 | Blood microparticle | C3, SERPING1, CLIC1, SERPINA3K, SERPINA3N, LGALS3BP, FGG, FGA, HPX, FGB, ITIH4, CFH, CP, FN1 | 3.79E−12 |
| GO:0005615 | Extracellular space | XDH, ALDOA, PZP, C3, S100A9, LGALS3BP, FGG, FGA, LRG1, FGB, CFH, FN1, ANXA1, SERPING1, CLIC1, LCN2, SERPINA3K, ORM1, SERPINA3N, SERPINA3H, HPX, SERPINA3G, CP, LCP1, CD14 | 9.32E−07 |
| GO:0005576 | Extracellular region | XDH, PZP, C3, S100A9, ANXA1, SERPING1, GBP2B, FTH1, LCN2, ORM1, SERPINA3K, SIGLEC1, FGG, SERPINA3N, LGALS3BP, FGA, HPX, FGB, ITIH4, CFH, CP, FGL1, CD14, FN1 | 9.38E−05 |
| GO:0005829 | Cytosol | XDH, G6PDX, VIM, ANXA1, UBA7, PML, PSMB8, STAT3, RAB7, CMPK2, PSMB9, LCN2, IGTP, HMOX1, HK3, TGM2, DPP9, PTPN1, LCP1, ZBP1, ARHGDIB | 0.009533 |
| GO:0030670 | Phagocytic vesicle membrane | H2-K1, IRGM1, TAP1, ANXA3, RAB7 | 0.037403 |
| GO:0009897 | External side of plasma membrane | H2-K1, FGG, FGA, FGB, H2-AA, CD74, CD14 | 1.601494 |
| GO:0009986 | Cell surface | EGFR, H2-K1, FGG, FGA, FGB, ANXA1, ITGB2, CD74, CD14 | 3.221346 |
| GO:0005737 | Cytoplasm | XDH, ALDOA, FKBP5, VIM, G6PDX, S100A9, PML, GBP2B, IQGAP1, RAB7, TPM3, FGG, FGA, FGB, ITIH4, TGM2, CFH, IIGP1, DPP9, ARHGDIB, ZBP1, EGFR, EPPK1, ANXA1, IFI44, CLIC1, PSMB8, ANXA3, STAT3, PSMB9, IFIT3, ARPC1B, IFIT1, SERPINA3G, PTPN1, GBP2, LCP1, MVP | 4.382999 |
| GO:0005925 | Focal adhesion | EGFR, ARPC1B, VIM, ANXA1, TGM2, IQGAP1, LCP1 | 4.50095 |
| GO:0005913 | Cell-cell adherens junction | EGFR, ALDOA, ANXA1, PTPN1, CLIC1, IQGAP1 | 8.377285 |
| GO:0005783 | Endoplasmic reticulum | EGFR, H2-K1, IRGM1, TAP2, HMOX1, TAP1, PLD4, PML, TGM2, IIGP1, PTPN1, CD74 | 12.93212 |
| GO:0016020 | Membrane | ALDOA, FKBP5, G6PDX, S100A9, PML, ITGB2, GBP2B, IQGAP1, CD74, RAB7, LGALS3BP, FAM49B, IGTP, TAP2, HMOX1, TAP1, TGM2, IIGP1, ARHGDIB, EGFR, H2-K1, IRGM1, GBP6, GATM, PLD4, ANXA1, CLIC1, ANXA3, SIGLEC1, GM12250, H2-AA, PTPN1, GBP4, GBP2, CD14, LCP1, MVP | 19.81221 |
| GO:0031012 | Extracellular matrix | LGALS3BP, VIM, S100A9, TGM2, FN1 | 27.42094 |
| GO:0031410 | Cytoplasmic vesicle | IRGM1, GBP6, ANXA1, PTPN1, GBP2B, GBP2, RAB7 | 36.50644 |
| GO:0005764 | Lysosome | IRGM1, LGMN, H2-AA, CD74, RAB7 | 37.37253 |
| Molecular function | |||
| GO:0003924 | GTPase activity | IRGM1, GBP6, IGTP, IIGP1, GBP2B, GBP4, GBP2, RAB7, ARHGDIB | 0.002934 |
| GO:0005525 | GTP binding | IRGM1, GBP6, IGTP, GM12250, TGM2, IIGP1, GBP2B, GBP4, GBP2, RAB7 | 0.034515 |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | SERPINA3K, SERPINA3N, PZP, SERPINA3G, ITIH4, SERPING1 | 0.196148 |
| GO:0030414 | Peptidase inhibitor activity | SERPINA3K, SERPINA3N, PZP, SERPINA3G, ITIH4, SERPING1 | 0.196148 |
| GO:0042802 | Identical protein binding | EGFR, IFIT3, VIM, G6PDX, IIGP1, DPP9, LCP1, STAT3, FN1 | 5.139194 |
| GO:0098641 | Cadherin binding involved in cell-cell adhesion | EGFR, ALDOA, ANXA1, PTPN1, CLIC1, IQGAP1 | 7.269523 |
| GO:0019901 | Protein kinase binding | EGFR, VIM, ITGB2, PTPN1, IQGAP1, STAT3, MVP | 10.86314 |
| GO:0005198 | Structural molecule activity | FGG, FGA, FGB, VIM, ANXA1 | 19.00636 |
| GO:0042803 | Protein homodimerization activity | LCN2, XDH, FGG, TAP2, HMOX1, TAP1, G6PDX, ANXA1, PML | 19.36988 |
| GO:0005515 | Protein binding | XDH, C3, VIM, PML, ITGB2, IQGAP1, CD74, RAB7, TPM3, LGALS3BP, FAM49B, TAP2, ITIH4, FN1, EGFR, PLD4, ANXA1, STAT3, IFIT3, LCN2, SERPINA3K, SIGLEC1, IFIT1, H2-AA, GBP4, LCP1 | 22.71878 |