| Properties |
Kaempferol |
Myricetin |
P-Hydroxycinnamic acid |
Quercetin |
| Blood-Brain Barrier |
BBB+ |
BBB− |
BBB+ |
BBB− |
| Human Intestinal Absorption |
HIA+ |
HIA+ |
HIA+ |
HIA+ |
| Caco-2 Permeability |
Caco2− |
Caco2− |
Caco2+ |
Caco2− |
| P-glycoprotein Substrate |
Substrate |
Substrate |
Substrate |
Non-substrate |
| CYP450 2C9 Substrate |
Non-substrate |
Non-substrate |
Non-substrate |
Non-substrate |
| CYP450 2D6 Substrate |
Non-substrate |
Non-substrate |
Non-substrate |
Non-substrate |
| CYP450 3A4 Substrate |
Non-substrate |
Non-substrate |
Non-substrate |
Non-substrate |
| CYP450 1A2 Inhibitor |
Inhibitor |
Inhibitor |
Non-inhibitor |
Inhibitor |
| CYP450 2C9 Inhibitor |
Inhibitor |
Non-inhibitor |
Non-inhibitor |
Non-inhibitor |
| CYP450 2D6 Inhibitor |
Non-inhibitor |
Non-inhibitor |
Non-inhibitor |
Non-inhibitor |
| CYP450 2C19 Inhibitor |
Inhibitor |
Non-inhibitor |
Non-inhibitor |
Non-inhibitor |
| CYP450 3A4 Inhibitor |
Inhibitor |
Inhibitor |
Non-inhibitor |
Inhibitor |
| CYP Inhibitory Promiscuity |
High CYP Inhibitory Promiscuity |
High CYP Inhibitory Promiscuity |
Low CYP Inhibitory Promiscuity |
High CYP Inhibitory Promiscuity |
| AMES Toxicity |
Non AMES toxic |
Non AMES toxic |
Non AMES toxic |
Non AMES toxic |
| Carcinogens |
Non-carcinogens |
Non-carcinogens |
Non-carcinogens |
Non-carcinogens |
| Biodegradation |
Not ready biodegradable |
Not ready biodegradable |
Ready biodegradable |
Not ready biodegradable |
| Acute Oral Toxicity |
II |
II |
III |
II |
| Carcinogenicity (Three-class) |
Non-required |
Non-required |
Non-required |
Non-required |