Factors

Levels(%w/w)

−1

0

+1

A

Level of Carbomer (Carbopol 974P)

4.17

6.67

9.17

B

Level of Povidone (Povidone K 90)

1.67

3.34

5

Responses

Goal

Acceptable Ranges

Y1

Drug release at 1 Hour in pH 6.8

In range

NMT 20

Y2

Drug release at 2 Hour in pH 6.8

In range

20 - 40

Y3

Drug release at 4 Hour in pH 6.8

In range

40 - 60

Y4

Drug release at 8 Hour in pH 6.8

In range

NLT 75