· Milling rate | · Drying method |
· Rate of addition of the granulating vehicle | · Screen size for initial sieving, during dry milling, during wet milling |
· Milling rates during wet granulation | · Hardness of tablets |
· Screen-sizes | · Shell size of capsule |
· Granulating time | · Mixing order |
· LOD of granule | · Blender type and blending time |
· Drying time | · Lubrication time |
· Drying condition | · Machine speed during compression and encapsulation |
· Speed of chopper and agitator during granulation | · Feeder speed |