· Milling rate

· Drying method

· Rate of addition of the granulating vehicle

· Screen size for initial sieving, during dry milling, during wet milling

· Milling rates during wet granulation

· Hardness of tablets

· Screen-sizes

· Shell size of capsule

· Granulating time

· Mixing order

· LOD of granule

· Blender type and blending time

· Drying time

· Lubrication time

· Drying condition

· Machine speed during compression and encapsulation

· Speed of chopper and agitator during granulation

· Feeder speed