Advantages of curcumin

Disadvantages of curcumin

It is useful for leukemia treatment due to anti-inflammatory and anti-oxidant properties.

By the use of high dosage of curcumin it affects the stomach and cause ulcer, vomiting and nausea.

Curcumin naturally exist as antioxidant and increase the antioxidant capability of your body to prevent free radicals production.

In some cases it cause allergic reactions in the body like shortness of breath, wheezing, rashes, irritation, burning in urine, hives and chest pain.

Curcumin inverse the cancer stages.

Avoid in pregnancy.

Curcumin has anti-cancer activity kills cancer cells during apoptosis in molecular pathways it does not kill normal cells. It prevents cancer from spreading due to anti-proliferative activity.

Avoid in suffering from bleeding disorder.

Curcumin inhibit the expression of NF-kappa B, Bcl-2 and activating caspase-3 and MAPK signaling. MMP-2 and MMP-9 are involved in inflammation turmeric also suppress them.

Discontinue prior to surgery.

In CLL curcumin inhibit different cancer survival pathways like STAT3, Akt or NF-kappa.

Avoid in suffering from gall bladder obstruction.

In AML curcumin suppress the DNA-Methyltransferase 1 and also prevent cancer growth.

It is advised not to take curcumin supplements concomitantly with any other medicine supplements are unregulated.

Curcumin have anti-angiogenic activity. It interferes with pathways such as protein kinase C and transcriptional factors. It also inhibits pro-angiogenic factors like VEGF and BFGF.

Curcumin not easily absorbed in the blood stream.

Curcumin radiosensitized the effect by the inhibtionofPI3K/Akt-dependent NF-kappa B pathway, it also enhances the sensitizing the effect of radiotheraphy.

Poor absorption.

It can reduce cancer risk if use curcumin in diet, it induce anti-apoptotic signals and regulate the changes in DNA to prevent cancer development.

More research is needed.