Advantages of curcumin | Disadvantages of curcumin |
It is useful for leukemia treatment due to anti-inflammatory and anti-oxidant properties. | By the use of high dosage of curcumin it affects the stomach and cause ulcer, vomiting and nausea. |
Curcumin naturally exist as antioxidant and increase the antioxidant capability of your body to prevent free radicals production. | In some cases it cause allergic reactions in the body like shortness of breath, wheezing, rashes, irritation, burning in urine, hives and chest pain. |
Curcumin inverse the cancer stages. | Avoid in pregnancy. |
Curcumin has anti-cancer activity kills cancer cells during apoptosis in molecular pathways it does not kill normal cells. It prevents cancer from spreading due to anti-proliferative activity. | Avoid in suffering from bleeding disorder. |
Curcumin inhibit the expression of NF-kappa B, Bcl-2 and activating caspase-3 and MAPK signaling. MMP-2 and MMP-9 are involved in inflammation turmeric also suppress them. | Discontinue prior to surgery. |
In CLL curcumin inhibit different cancer survival pathways like STAT3, Akt or NF-kappa. | Avoid in suffering from gall bladder obstruction. |
In AML curcumin suppress the DNA-Methyltransferase 1 and also prevent cancer growth. | It is advised not to take curcumin supplements concomitantly with any other medicine supplements are unregulated. |
Curcumin have anti-angiogenic activity. It interferes with pathways such as protein kinase C and transcriptional factors. It also inhibits pro-angiogenic factors like VEGF and BFGF. | Curcumin not easily absorbed in the blood stream. |
Curcumin radiosensitized the effect by the inhibtionofPI3K/Akt-dependent NF-kappa B pathway, it also enhances the sensitizing the effect of radiotheraphy. | Poor absorption. |
It can reduce cancer risk if use curcumin in diet, it induce anti-apoptotic signals and regulate the changes in DNA to prevent cancer development. | More research is needed. |