Action of curcumin

Effects of curcumin

As a result

AKT Pathway

Activation of P53 gene

Block the expression of (bcl2 and bax)

Repair DNA or apoptosis

ROS Pathway

Curcumin block the production of reactive oxygen species

Block transcriptional genes

Cause DNA cleavage and inhibit leukemic blast

NF-kB Inhibition

Block the entry of nuclear factors into nucleus

Inside the nucleus inhibit the activation of inflammatory genes

Block repair of DNA damage

ERK Pathway

Inhibit the phosphorylation of ERK, JNK, c-Jun JunB pathways and degradation of caspase-3

ERK1/2, JNK and downstream signaling proteins were increased

By the use of high dose it induce apoptosis in leukemic cells

FLT3 gene

Block the expression of FLT3 gene

further inhibit the RAS, STAT, AKT and ERK pathway

Inhibit growth promotion and differentiation and cause apoptosis