| Pathways | Action of curcumin | Effects of curcumin | As a result |
| AKT Pathway | Activation of P53 gene | Block the expression of (bcl2 and bax) | Repair DNA or apoptosis |
| ROS Pathway | Curcumin block the production of reactive oxygen species | Block transcriptional genes | Cause DNA cleavage and inhibit leukemic blast |
| NF-kB Inhibition | Block the entry of nuclear factors into nucleus | Inside the nucleus inhibit the activation of inflammatory genes | Block repair of DNA damage |
| ERK Pathway | Inhibit the phosphorylation of ERK, JNK, c-Jun JunB pathways and degradation of caspase-3 | ERK1/2, JNK and downstream signaling proteins were increased | By the use of high dose it induce apoptosis in leukemic cells |
| FLT3 gene | Block the expression of FLT3 gene | further inhibit the RAS, STAT, AKT and ERK pathway | Inhibit growth promotion and differentiation and cause apoptosis |