Parameter

Treatment Groups

Dose (mg/kg)

Normal Control

Diabetic Control

Glibenclamide

250 mg

500 mg

1000 mg

RBC (×10¹²/L)

8.18 ± 0.35

3.81 ± 0.40**

(53.42)

5.10 ± 0.62* (33.86)

6.21 ± 0.17* (62.99)

6.95 ± 0.30* (82.41)

8.64 ± 0.24* (126.77)

PCV (%)

47.16 ± 2.20

23.8 ± 1.68** (49.53)

38.02 ± 1.10* (59.75)

42.52 ± 0.65* (78.66)

46.98 ± 1.39* (97.39)

50.88 ± 0.93* (113.78)

HB (g/dL)

15.06 ± 0.17

9.79 ± 0.32** (34.99)

12.82 ± 0.46* (30.95)

14.12 ± 0.17* (44.23)

15.08 ± 0.17* (54.03)

16.14 ± 0.45* (64.86)

WBC (×10⁹/L)

8.24 ± 0.50

15.80 ± 0.54** (91.75)

11.51 ± 0.53* (−27.15)

10.28 ± 0.38* (−34.94)

9.35 ± 0.31* (−40.82)

7.35 ± 0.32* (−53.48)

MCV (fl)

68.61 ± 1.83

46.93 ± 3.27** ( 30.94)

62.00 ± 1.21* (32.11)

67.14 ± 4.05* (43.06)

68.08 ± 3.45* (45.07)

78.67 ± 8.79* (67.63)

MCH (pg)

22.80 ± 0.71

18.61 ± 1.14** (18.38)

18.73 ± 0.67 (0.64)

21.82 ± 0.74* (17.25)

26.37 ± 2.67* (41.70)

26.59 ± 2.20* (42.88)

MCHC (g/dL)

34.21 ± 1.37

21.54 ± 1.71** (37.04)

33.25 ± 0.81* (54.36)

31.77 ± 0.97* (47.49)

33.84 ± 1.58* (57.10)

39.55 ± 2.07* (83.61)

Platelet (×10⁹/L)

216.66 ± 6.92

804.22 ± 68.04** (271.19)

555.78 ± 20.67* (−30.89)

544.00 ± 31.51* (−32.36)

501.64 ± 28.17* (−37.62)

465.52 ± 19.24* (−42.12)

Lymphocytes (%)

56.54 ± 0.58

48.69 ± 1.08** (−13.88)

51.29 ± 0.87 (5.34)

51.48 ± 1.22 (5.73)

47.40 ± 0.94 (−2.65)

45.14 ± 1.29 (−7.29)

Monocytes (%)

13.93 ± 0.27

1.71 ± 0.14** (−91.60)

10.45 ± 0.55* (511.11)

13.97 ± 0.20* (716.96)

14.50 ± 0.26* (747.95)

16.80 ± 0.68* (882.46)

Neutrophils (%)

38.20 ± 0.33

36.42 ± 1.14 (−4.66)

37.76 ± 1.23 (3.68)

34.90 ± 0.62 (−4.17)

37.73 ± 1.48 (3.60)

36.79 ± 0.54 (1.02)

Eosinophils (%)

0.44 ± 0.11

2.31 ± 0.12** (425.00)

0.19 ± 0.04* (91.77)

0.09 ± 0.02* (96.10)

0.26 ± 0.07* (88.74)

0.62 ± 0.053* (73.16)

Basophils (%)

0.31 ± 0.07

1.29 ± 0.12** (316.13)

0.29 ± 0.03* (77.52)

0.08 ± 0.01* (93.8)

0.19 ± 0.04* (85.27)

0.57 ± 0.07* (55.81)