| Characteristic | ID 1 | ID 2 | ID 3* | ID 4** | ID 6* | |
| Intervention | Placebo | Placebo | Melatonin | Melatonin | Melatonin | |
| Age | 22 | 25 | 21 | 52 | 51 | |
| Preoperative visit |
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| |
|
| VAS pain (rest) | 0 | 0 | 0 | 0 | 1 |
|
| VAS pain (movement) | 0 | 0 | 0 | 0 | 0 |
|
| VAS anxiety | 3 | 0 | 50 | 0 | 4 |
|
| State anxiety | 35 | 25 | 32 | 27 | 24 |
|
| Trait anxiety | 42 | 29 | 45 | 31 | 32 |
| Morning of surgery |
|
|
|
|
| |
|
| KSS | 3 | 7 | 3 | 1 | 3 |
|
| Hours of sleep | 7 | 5.5 | 6.5 | 4 | 5 |
|
| Quality of sleep | 25 | 27 | 11 | 18 | 70 |
|
| Fatigue | 3 | 6 | 3 | 1 | 7 |
|
| Wellbeing | 25 | 31 | 1 | 100 | 50 |
| 60 min before surgery |
|
|
|
|
| |
|
| VAS anxiety | 21 | 18 | - | 2 | - |
|
| State anxiety | 33 | 31 | - | 43 | - |
| Intraoperative |
|
|
|
|
| |
|
| Remifentanil usage (µg) | 40 | 38 | - | 25 | - |
|
| Propofol usage (mL) | 62 | 238 | - | 41 | - |
| 1 hour postoperative |
|
|
|
|
| |
|
| VAS pain (rest) | 56 | 62 | - | 23 | - |
|
| VAS pain (movement) | 67 | 80 | - | 77 | - |
|
| VAS anxiety | 13 | 0 | - | 0 | - |
| 2 hours postoperative |
|
|
|
|
| |
|
| VAS pain (rest) | 66 | 18 | - | 38 | - |
|
| VAS pain (movement) | 77 | 36 | - | 77 | - |
|
| VAS anxiety | 21 | 0 | - | 6 | - |
| 4 hours postoperative |
|
|
|
|
| |
|
| VAS pain (rest) | 72 | 8 | - | 0 | - |
|
| VAS pain (movement) | 93 | 27 | - | 95 | - |
|
| VAS anxiety | 32 | 0 | - | 0 | - |
|
| State anxiety | 36 | 27 | - | 31 | - |
| 6 hours postoperative |
|
|
|
|
| |
|
| VAS pain (rest) | 35 | 11 | - | 18 | - |
|
| VAS pain (movement) | 35 | 28 | - | 20 | - |
|
| Opioid usage (oxycodon mg) | 10 | 10 | - | 17.5 | - |